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Pharm2 Chapter 40

QuestionAnswer
1. What is TB caused by a. Mycobacterium tuberculosis
2. How is TB transmitted a. By humans via droplets
3. Antitubercular drugs treat all forms of what a. Mycobacterium
4. How long does it take to have a positive reaction to a TB skin test a. 6-8 weeks
5. What happens in the first infectious episode stage of TB a. Mild pneumonia like illness
6. MDR (multi-drug resistant) TB is resistant to a. Both isoniazid and rifampin
7. What pt. teaching should be including when taking rifampin a. Body may turn orange along with urine, eyes, and skin
8. What is rifampin a. Broad spectrum, kills offending organism by inhibiting protein synthesis, available in PO and IV forms, used alone in prevention or in combination for tx
9. What is INH (isoniazid) a. Most widely used antitubercular drug, given single dose prophylaxis or in combo for tx, kills mycobacteria by disrupting cell wall synthesis, common form PO
10. INH is contraindicated in what type of pts a. Thos with pervious INH associated hepatic injury or any acute liver disease
11. First line antitubercular drugs are a. Isoniazid, rifapentine, rifampin
12. Second line antitubercular drugs are a. Amikacin, levofloxacin
13. What substance should be avoided at all costs when on antitubercular medications a. Alcohol!!
14. Protein wall synthesis inhibitors include a. Streptomycin, kanamycin, rifampin, rifabutin
15. Cell wall synthesis inhibitors include a. Cycloserine, ethionaminde, and isoniazid
16. What does the term bactericidal mean a. Kill bacteria
17. What does INH cause a. B6 deficiency and liver toxicity
18. What should be given with INH a. Pyridoxine (b6) 50mg
19. Rifampin can cause a. Hepatitis and urine/ stool discoloration
20. You should perform what before administering an antitubercular drug a. Liver function studies and assess contraindications
21. What is the major reason MDR develop a. Noncompliance to drug regiment
22. How long may therapy last on an antitubercular drug a. 24 months
23. Drugs are given how long after cultures become negative a. 1-2 years
24. You should monitor what in pts with diabetes when taking an antitubercular drug a. Blood glucose and signs of hyperglycemia
25. INH and rifampin do what to contraceptives a. Cause them to become ineffective, other forms will be needed
26. B6 (pyridoxine) may be needed to combat what a. Neurologic side effects associated with INH therapy
Created by: cspearsall
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