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Pharm C48

TermDefinition
Warfarin is an... anticoagulant
Warfarin therapeutic actions interfere with the normal cascade of events involved in the clotting process
Warfarin causes decrease in... vitamin K which causes blood to thin
Vitamin K counteracts... Warfarin
Warfarin pharmacokinetics taken orally, absorbed readily through the GI tract, metabolized in the liver and excreted in the urine and feces, onset action of 3 days and effect lasts 4-5 days
Warfarin Contraindications and cautions HF, thyrotoxicosis, senility, psychosis
Warfarin adverse effects Bleeding, alopecia and dermatitis, bone marrow depression, prolonged and painful erection, GI upset, diarrhea, hepatic dysfunction
Warfarin Drug-drug interactions Has documented drug-to-drug interactions with a vast number of other drugs, do not eat green leafy vegetables when on heparin
Discharge teaching for client on anti-coagulation therapy -brush teeth softly with soft bristle tooth brush -wear medical alert bracelet -instruct on warning signs of bleeding -instruct pt to obtain follow-up labs regularly
Urokinase indications lysis of PE or PE with unstable hemodynamics in adults
Urokinase actions Converts endogenous plasminogen to plasmin, which breaks down fibrin clots, fibrinogen, and other plasma proteins, lyses thrombi and emboli
Urokinase adverse effects headache, angioneurmtic edema, hypotension, skin rash, bleeding, breathing difficulties, bronchospasm, pain, fever, anaphylactic shock
Clotting factors and liver disease Liver disease, in which clotting factors and proteins needed for clotting are not produced
Created by: aleahgoodson
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