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Sinemet
Anti-Parkinson's Medications: levodopa/carbidopa (Sinemet)
Question | Answer |
---|---|
What is the prototype drug for this class? | levodopa/carbidopa (Sinemet) |
What are symptoms of Parkinson's Disease? (5) | 1.) shaking 2.) tremors 3.) difficulty speaking 4.) shuffled gait 5.) decreased levels of dopamine |
How does this medication work? (3) | 1.) Promotes dopamine synthesis 2.) Activate dopamine receptors 3.) Prevent dopamine breakdown |
What does this medication provide? Give examples (3) | Symptomatic relief from dyskinesias 1.) bradykinesia 2.) resting tremors 3.) muscle rigidity |
What does this medication help increase? | The ability to perform ADLs |
What is a disadvantage of this medication? | It tends to "wear off" after 5 years of treatment |
Being that this drug a combination drug, how does each medication work? (2) | 1.) levodopa crosses the blood-brain barrier & is converted to dopamine 2.) carbidopa is used to augment levodopa by DECREASING the amount of levodopa that is CONVERTED to dopamine in the intestines & periphery (allows more to reach CNS) |
What is the biggest adverse effect of this medication? (3) | Nausea/vomiting/drowsiness |
How do you prevent N/V/drowsiness? | Administer WITH food |
What kind of food should the patient avoid eating and why? | Avoid taking with foods HIGH IN PROTEIN or PYRIDOXINE This inhibits & reduces the effects of the drug |
What vital signs should the nurse monitor while their patient is taking this medication? Why? (2) | 1.) Blood pressure because this medication can cause orthostatic hypotension 2.) ECG because this medication can cause tachycardia & palpitations |
Why do the cardiovascular effects take place? | The sympathetic NS has been activated |