Condition | Neoplasm |
Down syndrome | ALL (we ALL fall Down) AML |
Xeroderma pigmentosum, albinism | Melanoma and basal, squamous cell carcinomas of skin |
Chronic atrophic gastritis, pernicious anemia, post surgical gastric remnants | Gastric adenocarcinoma |
Tuberous sclerosis (facial angiofibroma, seizures, mental retardation) | Astrocytoma and cardiac rhabdomyoma |
Actinic keratosis | Squamous cell carcinoma of skin |
Barrett's esophagus (chronic GI reflux) | Esophageal adenocarcinoma |
Plummer-Vinson syndrome (atrophic glossitis, esophageal webs, anemia; all due to iron deficiency) | Squamous cell carcinoma of esophagus |
Cirrhosis (alcoholic, hepatitis B or C) | Hepatocellular carcinoma |
Ulcerative colitis | Colonic adenocarcinoma |
Paget's disease of bone | 2° osteosarcoma and fibrosarcoma |
Immunodeficiency states | Malignant lymphomas |
AIDS | Aggressive malignant lymphomas (non-Hodgkin's) and Kaposi's sarcoma |
Autoimmune diseases (e.g., Hashimoto's thyroiditis, myasthenia gravis) | Benign and malignant thymomas |
Acanthosis nigricans (hyperpigmentation and epidermal thickening) | Visceral malignancy (stomach, lung, breast, uterus) |
Dysplastic nevus | Malignant melanoma |