Question | Answer |
types of Paget's Disease | intraepithelial adenocarcinoma
bone: xs bone resorption as result of inflammatory response
breast: malignant condition with skin changes involving nipple
extramammary: involves primarily epidermis but occasionally extends into underlying epidermi |
endometriosis | can occur anywhere in the body
deposition of 2 outta 3:
1)endometrial glands
2)endometrial stroma
3)hemosiderin
major cause of infertility and pelvic pain
origin: regurgitation thru FT, dissem. thru veins/lymphatics, metaplasia from coelomic e |
low grade squamous intraepithelial lesions
LGIL, LGSIL | CIN I-moderate dysplasia |
high grade squamous intraepithelial lesions | CIN II-moderate dysplasia
CIN III-severe dysplasia |
tamoxifen | used as anti-estrogen therapy for hormone-receptor positive breast cancer in pre-menopausal women |
salpingitis | infxn and inflamm of FT
2 types:
1)acute
2)chronic=change in architecture
TB play big role in salpingitis worldwide; PID in U.S. |
salpingitis isthmica nosdosum | diverticulosis of FT: thickening of tunica musclaris of isthmic portion leads to complete obliteration of tubal lumen
usually bilateral |
Stein-Leventhal syndrome | polycystic ovarian syndrome
follicular cysts, anovulation, obesity, hirsutism |
benign germ cell tumor | mature teratoma
ectodermally derived
frequently skin, respiratory, conjunctiva epithelium
any component of teratoma can develop a "mature malignancy" |
malignant germ cell tumors | dysgerminoma
embryonal
immature teratoma
yolk sac
choriocarcinoma |
dysgerminoma | malignant germ cell tumor
undifferentiated
ovarian counterpart of seminoma
large vesicles with clear cytoplasm
prominent lymphoid component |
embroynal tumor | malignant germ cell tumor
primitive |
immature teratoma | malignant germ cell tumor
somatic: resembles differentiation seen in fetus or embryo |
yolk sac tumor | malignant germ cell tumor
extraembryonic
rich in AFP
Schiller Duval Body |
choriocarcinoma | malignant germ cell tumor
placental or ovarian origin
cytotrophoblasts and syncytiotrophoblasts present |
surface epithelial tumors | 1)serous
2)mucinous
3)pseudomyxoma peritonei |
tumor metastasis to ovaries | most common origin from gyn system
2nd common origin from digestive tract |
Krukenburg tumor | malignancy in ovaries that metastasized from stomach cancer
found 80% in both ovaries |