Question | Answer |
Symmetric proximal and distal weakness with sensory loss | GBS, CIDP |
Symmetric distal weakness with sensory loss | Drug-induced, toxic, and metabolic neuropathies; hereditary neuropathies; amyloidosis |
Asymmetric distal weakness with sensory loss - multiple nerves | Vasculitis; HHNPP; infections such as leprosy, Lyme disease, sarcoidosis, and HIV |
Asymmetric distal weakness with sensory loss - single nerve | Compressive mononeuropathy and radiculopathy |
Asymmetric distal weakness without sensory loss | Motor neuron disease, multifocal motor neuropathy |
Asymmetric proximal and distal weakness with sensory loss | Polyradiculopathy or plexopathy, meningeal carcinomatosis or lymphomatosis, HNPP, hereditary neuropathies |
Symmetric sensory loss without weakness | Crytogenic sensory polyneuropathy; metabolic, drug-induced, or toxic neuropathies; leprosy |
Asymmetric proprioceptive sensory loss without weakness | Sensory neuronopathies (ganglionopathies); consider paraneoplastic, Sjogren syndrome, vitamin B6 toxicity, HIV-related sensory neuronopathies, cis-platinum toxicity |
Autonomic symptoms and signs | Diabetes mellitus, amyloidosis, GBS, vincristine, porphyria, HIV-related autonomic neuropathy, idiopathic pandysautonomia |