Question | Answer |
Maternal prenatal stress/depression is associated with.. | low infant birth weight and prematurity, also temperament and behavior |
Women with schizophrenia or a major affective disorder have an increased risk for... | fetal distress, abruptio placenta, IUGR, and babies with heart defects |
When compaired to babies whose mothers were depressed but took no meds, babies exposed to SSRIs had... | lower birth weight, gestational age, respiratory distress, jaundice and feeding problems |
Antidepressants and pregnancy: SSRIs (and tricyclics) | Low risk for malformations, risk for problems in newborn period |
Antidepressants and pregnancy: Paxil | small increase risk for heart defects (~1%), significant problems for newborn adaptation |
Antidepressants and pregnancy: Effexor | significant problems with newborn adaptation |
Antidepressants and pregnancy is a... | continued area of study, risk is unlikely to be large but unlikely to be zero |
SSRIs and neonatal adaption: neonatal behaviorial syndrome | CNS (Irritability and agitation), Motor (tremors, increased muscle tone), respiratory distress, GI difficulties, onset between birth and 3 weeks and typically lasts less than two weeks |
Neonatal behaviorial syndrome most implicated with what 3 drugs | Paxil, Prozac and Effexor |
Medical management for Neonatal adaptation syndrome | Supportive care in the NICU, toxicity versus withdrawal.. occasionally small doses of the maternal medication are administered |
FDA says (with SSRIs) 3rd trimester exposure leads to... | 20-30% risk for neonatal behavioral syndrome and 1% risk for PPHN |
Lithium | (~1%) risk for Ebstein's anomaly, fetal echocardiogram at 20 weeks is recommended. 3rd trimester has been associated with LOTS OF stuff... |
Lithium in 3rd trimester... | neonatal cyanosis, hypotonia, cardiac rhythm disturbances, diabetes insipidus and hypothyroidism |
Antipsychotics: Haldol | limb defects, extrapyramidal effects in third trimester |
Antipsychotics: Risperdal | Reassuring!!!! |
Antipscyhotics: Zyprexa | Reassuring. But maternal weight gain may lead to OB complications |
Infants and breastfeeding: Long term effects of psychotropics on neurocognitive development are... | largely unknown |
Infants and breastfeeding: Potential acute efects of SSRIs on infants | |
Maternal prenatal stress/depression is associated with.. | low infant birth weight and prematurity, also temperament and behavior |
Women with schizophrenia or a major affective disorder have an increased risk for... | fetal distress, abruptio placenta, IUGR, and babies with heart defects |
When compaired to babies whose mothers were depressed but took no meds, babies exposed to SSRIs had... | lower birth weight, gestational age, respiratory distress, jaundice and feeding problems |
Antidepressants and pregnancy: SSRIs (and tricyclics) | Low risk for malformations, risk for problems in newborn period |
Antidepressants and pregnancy: Paxil | small increase risk for heart defects (~1%), significant problems for newborn adaptation |
Antidepressants and pregnancy: Effexor | significant problems with newborn adaptation |
Antidepressants and pregnancy is a... | continued area of study, risk is unlikely to be large but unlikely to be zero |
SSRIs and neonatal adaption: neonatal behaviorial syndrome | CNS (Irritability and agitation), Motor (tremors, increased muscle tone), respiratory distress, GI difficulties, onset between birth and 3 weeks and typically lasts less than two weeks |
Neonatal behaviorial syndrome most implicated with what 3 drugs | Paxil, Prozac and Effexor |
Medical management for Neonatal adaptation syndrome | Supportive care in the NICU, toxicity versus withdrawal.. occasionally small doses of the maternal medication are administered |
FDA says (with SSRIs) 3rd trimester exposure leads to... | 20-30% risk for neonatal behavioral syndrome and 1% risk for PPHN |
Lithium | (~1%) risk for Ebstein's anomaly, fetal echocardiogram at 20 weeks is recommended. 3rd trimester has been associated with LOTS OF stuff... |
Lithium in 3rd trimester... | neonatal cyanosis, hypotonia, cardiac rhythm disturbances, diabetes insipidus and hypothyroidism |
Antipsychotics: Haldol | limb defects, extrapyramidal effects in third trimester |
Antipsychotics: Risperdal | Reassuring!!!! |
Antipscyhotics: Zyprexa | Reassuring. But maternal weight gain may lead to OB complications |
Infants and breastfeeding: Long term effects of psychotropics on neurocognitive development are... | largely unknown |
Infants and breastfeeding: Potential acute efects of SSRIs on infants | GI Disturbances (Prozac), irritability, somnolence |
Potential long term effects of SSRIs while breastfeeding | Neurobehavioral changes, decreased wt gain |
Mood stabilizers | American Academy of Pediatrics classifies lithium as not compatible with breastfeeding |