| Question |
Answer |
| Folic acid analog that inhibits dihydrofolate reductase | Methotrexate |
| Pyrimidine analog that inhibits thymidylate synthase | 5-fluorouracil |
| Inhibitor of de novo purine synthesis | 6-mercaptopurine |
| Inhibits DNA polymerase | cytarabine |
| Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. Notable side effect of hemorrhagic cystitis | Cyclophosphamide, ifosfamide |
| Alkylating agent capable of crossing blood brain barrier | Nitrosureas (carmustine, lomustine) |
| Similar to alkylating agent, notable toxicities include nephrotoxicity and acoustic nerve damage | Cisplatin, carboplatin |
| Alkylating agent used to treat CML | Busulfan |
| Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) | Doxorubicin (Adriamycin), daunorubicin |
| Used to treat childhood tumors (Wilm's tumor, rhabdomyosarcoma, and Ewing's sarcoma) | Dactinomycin (Actinomycin D; Children ACT out)
|
| Free radical generator which can cause life threatening pulmonary fibrosis | Bleomycin |
| Topoisomerase II inhibitor | Etoposide |
| Steroid that triggers apoptosis | Prednisone |
| Estrogen receptor antagonist | Tamoxifen
|
| Monoclonal antibody against HER-2 | Trastuzumab |
| Philadelphia chromosome bcr-abl tyrosine kinase inhibitor | Imatinib (Gleevec) |
| Binds tubulin blocking polymerization of microtubules and mitotic spindle formation | Vincristine, vinblastine |
| Binds tubulin hyperstabalizing microtubules and blocking mitotic spindle formation | Paclitaxel |
| Toxicity includes Cushing-like symptoms | Prednisone |
| Used for "metastatic" breast cancer | Trastuzumab |
| Increased risk of endometrial carcinoma | Tamoxifen |
| Do not use with allopurinol | 6-mercaptopurine (activated by xanthine oxidase; allopurinol is a xanthine oxidase inhibitor used to treat gout) |
| CNS toxicity | Nitrosureas (carmustine, lomustine |
| Reversible myelosuppression with leucovorin rescue | Methotrexate |
| Neurotoxic (areflexia, peripheral neuritis) paralytic ileus | Vincristine (Vinblastine is notable for bone marrow suppression) |
| Antineoplastic used for therapeutic abortion | Methotrexate |
| Androgen receptor antagonist | Flutamide |
| Recombinantly produced cytokine used to treat hairy cell leukemia | Interferon alpha |
| GnRH agonist used for the treatment of metastatic prostate carcinoma | Leuprolide, Goserelin, Nafarelin |
| Monoclonal antibody used for treatment of low grade non-Hodgkin lymphoma | Rituximab |
| Aromatase inhibitor used to treat breast cancer | Anastrozole |
Ch.18 LTI-MA 509
