Question | Answer |
Hemicholinium | Stops Ach synthesis... by blocking re uptake of choline |
Vesamicol | Prevents storage of Ach |
Botulinus toxin | blocks release of Ach |
Latrotoxin | Causes explosive release of Ach |
Physostigmine | inhibits Ach metabolism |
Muscarine | Activation of the postsynaptic receptor binding(muscuranic) |
Atropine | Blockade of the postsynaptic receptor binding(muscuranic) |
Nicotine | Activation of the postsynaptic receptor binding(nicotinic) |
Mecamylamine | Blockade of the postsynaptic receptor binding(nicotinic- neuronal) |
Tubocurarine | Blockade of the postsynaptic receptor binding(nicotinic- muscular) |
Where are nicotinic neuronal found? | Ganglionic neurons, adrenal medulla, some
presynaptic cholinergic terminals, CNS
neurons. |
Where are nicotinic muscular found? | Skeletal neuromuscular endplates. |
Where are M1 Receptors found? | Ganglionic neurons, some presynaptic
terminals, CNS neurons. |
Where are M2 Receptors found? | Myocardium, presynaptic terminals,
ganglionic neurons, some smooth muscle,
CNS neurons. |
Where are M3 Receptors found? | Smooth muscle, exocrine glands, vascular
endothelium, CNS neurons. |
Metyrosine | Blocks NE synthesis |
Reserpine | Prevents storage OF ne |
Guanethidine | Prevent the release of NE |
Tyramine
Amphetamine | Promote release of NE |
Cocaine,
Tricyclic antidepressants | Inhibit reuptake of NE |
MAO inhibitors | inhibit NE metabolism |
Epinephrine | Alpha-1 and Alpha-2 receptor
binding receptor activation |
Prazosin | Alpha-1 receptor
binding receptor block |
Yohimbine | Alpha-2 receptor
binding receptor block |
Dobutamine | Beta-1 receptor
binding receptor activation |
Metoprolol | Beta-1 receptor
binding receptor blockade |
Albuterol | Beta-2 receptor
binding activation |
Butoxamine | Beta-2 receptor
binding block |