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E coli
Question | Answer |
---|---|
what are the non-inflammatory E coli illnesses? (do not see fecal WBCs) | Enterotoxigenic (ETEC), Enteropathogenic (EPEC), Enteroaggregative (EAggEC) |
E coli that cause invasive disease | Enteroinvasive (EIEC), Enterohemorrhagic (EHEC) |
ETEC characteristics | **traveler's diarrhea** abrupt onset watery diarrhea, lasts 24 hours long after fluids replaced, Toxins |
ETEC toxins | Heat labile toxin- A-B toxin like cholera......Heat stable toxin- stimulates cGMP and secretes Cl- into the lumen ( osmotic diarrhea) |
EPEC characteristics (no toxin) | **most common in children**attach to ep cells and disrupt microvilli.. unique type III secretory system |
EPEC attachment | Tir receptors put in ep cell and intimin put on bacterial cell....causes actin rearrangement a pedestal emerges from the cell |
EAggEC characteristics | *** persistent diarrhea*** 3 stages (1. adhere to mucous, 2. enhance mucous formation, 3. cytotoxin damages cell) |
Treatment for inflammatory E. coli infections | replace fluids and antibiotics may help shorten duration |
EIEC characteristics | similar pathogenesis to Shigella (shiga toxin kills cells, lives intracellularly) watery diarrhea |
EHEC characteristics | ***most infect large bowel***, kidney damage from shiga toxin, Hemorrhagic colitis or hemolytic uremic syndrome |
Hemolytic uremic syndrome is.... | triad of symptoms...1. renal failure 2. thrombocytopenia 3. microangiopathic hemolytic anemia |
diagnosis and treatment of invasive E. coli | EHEC----0157:H7--inability to ferment sucrose----avoid antibioitics (may release more toxin) |
listeria monocytogenes seen in..... | maternal infection during pregnancy |