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WVSOM skin System 2012- adelman Wound healing

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Question
Answer
What are the phases of wound healing?   Inflammatory phase, migratory phase, proliferative phase, late phase scare remodeling  
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Name the portions of the inflammatory phase?   Hemostasis, vasodilation, phagocytosis  
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what occurs during hemostasis?   Vasoconstriction, platelet aggregation, release of cytokines, release of factor XII,  
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What occurs during vasodilation?   increased permeability for plasma proteins, RBC's, WBC's  
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how long does vasodilation last?   5-7 days  
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What cells are involved with phagocytosis?   Macrophages and Neutrophils, PMN leukocytes, Monocyte  
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What can monocytes transition to?   macrophages  
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How long does the migratory phase last?   lasts 2days- 3 weeks  
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What is the priniciple action of the migratory phase?   Angiogenesis, epitheialization  
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define the epithelial response   Marginal basal cells undergo increased mitosis, daughter cells flatten to fill void  
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when does the proliferative phase begin?   5 days after wound occurs  
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define fibroplasia   undifferentiated, extravascular mesenchymal cells transform to fibroblasts stimulated by injury  
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When does fibroplasia begin?   5-7 post wound  
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What is the major collagen component of skin tissue   Type I  
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What is the second most common collagen component of skin tissue?   Type III  
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what makes collagen? what does it require?   Fibroblast; o2, ascorbic acid (vit C)and ferrous iron  
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how does collagen contract?   Myofibroblasts  
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what structural component is important for scar formation?   Cross-linkage to increase strength  
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Nutrition is important to wound healing. What occurs in the malnourished?   visceral and cuntaneous wound healing is stalled only in SEVERELY malnourished  
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what would an asorbic acid deficiency cause?   lack of hydroxylation of proline and lysine in collagen synthesis  
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what would a zinc deficency cause?   decreased cellular proliferation and granulation.  
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what would a zinc overdose cause?   inhibition of macrophage migration and phagocytosis  
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what affect does anemia and hypoxia have on wound healing?   HYPOXIA: inability to form collagen (hydroxylation of proline and lysine) ANEMIA: must be severe enough to limit circulating blood volume.  
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what is the effect of steroids on wound healing?   Adrenocortical steroids inhibit all aspects of healing.  
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when would you use steroids therapeutically?   KELOIDS  
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What can exaccerbate Keloid formation?   Vitamin A  
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Created by: Bwest8
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