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Path Y2B2

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.

malaria   feed on Hb of erythrocytes; p. vivax attach to rbc via Duffy blood group antigen   protozoa  
f. falciparum   "malignant" form of malaria   protozoa  
f. falciparum   PfEMP1 - makes rbc stick together (microcirulation disturbed)   protozoa  
babesiosis   Ixodes sp. (hard tick); DD: lyme disease and/or erlichiosis, minority of pts will manifest mixed infections   protozoa  
leishmaniasis   usu called by L.mexicanan and L. donovani; TX southward   protozoa  
leishmaniasis   inflammatory papule which usu ulcerates, at the site of the bite (bagdad boil) followed by regional lymphadenopathy; parasite remains   protozoa  
visceral leishmaniasis   (Kala Azar - India and Brazil) caused by L. donovani   protozoa  
visceral leishmaniasis   Sx: papule at bite; asym., splenomegaly, anemia   protozoa  
visceral leishmaniasis   result in intrauterine transmission and congenital visceral leishmaniasis and cutaneous leishmaniasis   protozoa  
visceral leishmaniasis   disseminated can lead to multi-organ dysfxn and immune deficiency which predisposes to other infections   protozoa  
chagas disease   infects leukocytes initally and other cells of the body after dissemination via blood and lymphatics   protozoa  
chagas disease   infect myocardium; neurons of myenteric plexus -- esophagus, colon, ureters   protozoa  
chagas disease   acute - inflammatory papule, lymphadenopathy, hepatospl.; latent - may last a few yrs; symptomatic - minority of pts: heart, bowel, CNS   protozoa  
chagas disease   clinical manifestations often includes a combo of myocarditis, dilation of the esophagus, dilation of teh colon, and dilation of the ureter   protozoa  
strongyloidiasis   autoinfection can lead to disseminated hyperinfection w/ invasion of a number of internal organs   worm  
strongyloidiasis   in pt taking high doses of corticosteroids, chronic pneumonitis, incrased incidence of bac sepsis d/t bowel wall damage from invasive larvae   nematode  
strongyloidiasis   only helminth able to complete entire life cycle in human host which can lead to autoinfection   nematode  
cysticercosis   man ingests EGGS rather than encysted larva, becoming the intermediate (not definitive) host   cestode  
cysticercosis   eggs rise larvae which penetrate the bowel (CNS, eyes, skeletal muscle, subq)   cestode  
neurocysticercosis   high mortality rate and leads to the formation of multiple small cysts in the brain often exhibiting dystrophic clacification (seizures, hydrocephalus, chronic meningoencephalitis)   cestode  
echinococcus species   larvae disseminate to the lungs and liver where they form hydatid cysts in humans (liver - multilocular)   cestode  
ecinococcus species   larvae multiply in cysts which enlarge over yrs; can go to other organs   cestode  
schistosomiaiss   trematode infections can be classified based on the tissue invaded by adult flukes (blood, liver, lung, intestine)   trematode  
schistosomiaisis   "swimmer's itch" cercarial dermatitis   trematode  
schistosomiaisis   Katayama syndrome (fever, lymphadenopathy, hepatospl.)   trematode  
schistosomiasis   chronic form depends on tissue tropism of liver, intestinal, pelvic/urinary   trematode  
schistosomiaisis   blood fluke, S. haematobium = squamous cell carcinoma of bladder   trematode  
schistosomal dermatitis   non-path to humans as terminal hosts; enzymes for penetration cause intense inflammation and itching after abt 12 hrs   trematode  
lymphatic filariasis   intense granulomatous inflammatory response leading to lymphatic channel obstruction and lymphedema (elephantitis)   nematode  
acquired toxoplasmosis   injest meat, or ingest sporulated oocysts present in cat feces   protozoa  
acquired toxoplasmosis   in immune deficient pts, it can lead to necrotizing lesions in the CNS, heart, lungs, eyes   protozoa  
acquired toxoplasmosis   most common organ is CNS   protozoa  
congenital toxoplasmosis   first trimester = low; second trimester = transmission to fetus almost always occurs, but effects on fetus are minimal   protozoa  
congenital toxoplasmosis   toxoplasmosis triad: chorioretinitis, hydrocephalus, cerebral calcificaiton   protozoa  
entamoeba histolytica   bowel mucosa ulcerations; 1 in 20 cases complicated by intestinal perforation   protozoa  
entamoeba histolytica   amebic abscess in the liver; disseminated amebiasis is uncommon in immunocompetent, but does occur   protozoa  
entamoeba histolytica   amebic colitis w/ mucosal inflammation and ulceration   protozoa  
entaoeba histolytica   ameboma is tumor-like chronic inflammatory proliferation in the wall of the colon; systemic spread including lung, skin and liver   protozoa  
Giardiasis   acute and chronic gastritis and/or enterocolitis but does NOT cause dysentery   (blank)  
trichomonas   asym carriers; non-invasive infection in females (vaginitis) or males (urethritis); rarely causes cystitis in females or prostatitis in males   (blank)  
trichomonas   strawberry cervix sign is highly correlated w/ T. vaginalis infection   (blank)  
cryptosporidiasis   diarrhea; self-limited in immunocompetent; can lead to chronic diarrhea - malnutrition and dehydration via systemic dissemination   (blank)  
ascariasis   chronic malnutrition; worms consume 10% of food   (blank)  
ascariasis   intestinal obstruction due to heavy worm pop; infrequently causes bilary tract obstruction   (blank)  
enterobius vermicularis   perianal pruritis (usu nocturnal)   (blank)  
hookworms   serpiginous rash; cutaneous larva migrans   (blank)  
hookworms   pneumonic phase; intestinal phase (iron deficiency anemia) -- sequele   (blank)  
cutaneous larva migrans   self-limiting disease w/ cutaneous larvae dying and lesions resolving w/in 4-8wks   (blank)  
cutaneous larva migrans   secondary bac infection is common (s. aureus or s. pyogenes)   (blank)  
clonorchiasis   infects the bile passages; markedly increased incidence of suppurative cholangitis leading to acute biliary tract obstruction   flukeworm  
fascioliasis   markedly increased incidence of suppurative cholangitis leading to acute biliary tract obstruction   flukeworm  
fascioliasis   cliinal synopsis: spontaneous pneumothorax, chronic coughing, chronic dyspnea   flukeworm  
dermatobiasis   botfly lays eggs on stomach of mosquite or other blood sucking insect   (blank)  
dermatobiasis   eggs into human skin from bite; warble: larvae burrowed under skin   (blank)  
dermatobiasis   NOT systemic, just remove from skin   (blank)  
scabies   intense prutitis; linear erthematous lesions are often a/w inflammatory papules   (blank)  
scabies   burrowing females avoid hairy areas: wrist, sides of fingers/feet, penis   (blank)  


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