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Top 200 #9

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Class
Brand
Generic
Indication
Dose Form
Route
Adult Dose
Ped Dose
MOA
Biphasic Contraceptive Combo (Estrogen and Progestin)   Kariva; Mircette; Ortho Novum 10/11   Biphasic Contraceptive Combo   Contraception   Varies   Oral   1 tab QD, same time each day   Safety & efficacy before menarche have not been established   “see mono”  
Triphasic Contraceptive Combo (Estrogen and Progestin)   Ortho Tri-Cyclen; Ortho Tri-Cyclen Lo; Tri-Sprintec; Trivora   Triphasic Contraceptive Combo   Contraception   Varies   Oral   1 tab QD, same time each day   Safety & efficacy before menarche have not been established   “see mono”  
Contraceptive; Endocrine-Metabolic Agent; Progestin   Nor-QD; Micronor; Camila   Norethindrone   Contraception   Oral Tablet: 0.35mg   Oral   1 tab QD, same time each day   Safety & efficacy before menarche have not been established   Prevents ovulation, inhibits sperm penetration by thickening the cervical mucus, reduces midcycle luteinizing hormone & follicle-stimulating hormone peaks, delays the movement of ovum through the fallopian tube and alters the endometrium lining  
Contraceptive Estrogen and Progestin Combo   NuvaRing   Ethinyl Estradiol/ Etonogestrel   Contraception   Vaginal Insert (ER): 0.015mg-0.12mg/24hr   Vaginally   Insert 1 ring and wear continuously for 3 weeks, remove for 1 week and repeat with a new ring   Safety & efficacy before menarche have not been established   Suppresses gonadotropins; inhibits ovulation; changes cervical mucus and the endometrium  
Antineoplastic Agnet; Contraceptive; Progestin; Endocrine-Metabolic Agent   Provera   Medroxyprogesterone   Abnormal uterine bleeding unrelated to menstrual cycle; contraception; endometrial hyperplasia; endometriosis; 2® physiologic amenorrhea   Oral Tablet: 2.5, 5, 10mg; SubQ Susp: 104mg/0.65ml IM Susp: 150mg/ml, 400mg/ml;   IM, Oral, SubQ   Tablets: dosing varies; IM injection: done once every 3 months   N/A   Has androgenic & anabolic effects; transforms proliferative into secretory endometrium in women with adequate endogenous estrogen  
Endocrine-Metabolic Agent; Estrogen; Female Reproductive Agent   Premarin   Estrogens (conjugated)   Abnormal vasomotor function, dyspareunia – menopause; atrophic vulva; carcinoma of prostate; decreased estrogen level; dysfunctional uterine bleeding; metastatic breast cancer   IV Powder for Soln: 25mg; Oral Tablet: 0.3, 0.45, 0.625, 0.9, 1.25mg; Vaginal Cream: 0.625mg/gm   IV, Oral, Vaginally   Varies   N/A (however, estrogen therapy has been used for induction of puberty)   Binds to nuclear receptors in estrogen-responsive tissues; modulates the pituitary secretion of the gonadotropins, LH, FSH, through a negative feedback mechanism, reducing the levels of these hormones seen in postmenopausal women  
Endocrine Metabolic Agent; Selective Estrogen Receptor Momdulator   Evista   Raloxifene   Breast Cancer, Osteoporosis   Oral Tablet: 60mg   Oral   60mg QD   N/A   (SERM) selectively activates and blocks estrogenic paths by binding to specific estrogen receptors  
Nutriceutical; Nutritive Agent; Vitamin B   Folic Acid   Folic Acid   Megaloblastic Anemia,folic acid deficiency   Inj. Soln: 5mg/ml;cap:5mg,2000mcg Oral Tablet: 0.4mg, 0.8mg, 1mg, 800mcg   Oral, SubQ, IV, IM   Deficiency:0.4-0.8mg/day; homocystinemia:0.5-5mg/day; Pregnancy prophylaxis:0.4-1mg/day   Deficiency;megaloblastic anemia :infants 0.1mg/d;<4yo 0.3mg/d;>4yo 0.4mg/d   After conversion to tetrahydrofolic acid, it’s necessary for erythropoiesis, synthesis of purine and thymidylates, metabolism of amino acids (gly. and met. and the metabolism of histidine  
Antimuscarinic; Urinary Antispasmodic   Detrol; Detrol LA   Tolterodine   Overactive Bladder   Oral Tablet: 1, 2 mg; ER Capsule: 2, 4 mg   Oral   IR Tablet: Initial= 2mg BID, may lower dose to 1mg BID; ER Tablet: Initial= 4mg QD, may lower dose to 2mg QD   N/A   Competitive muscarinic receptor antagonist, mediating contraction of the urinary bladder and enhances salivation  
Antimuscarinic; Urinary Antispasmodic   Vesicare   Solifenacin   Overactive Bladder   Oral Tablet: 5, 10mg   Oral   5-10mg QD   N/A   Exerts competitive antagonists effects at the muscarinic receptor  
Αlpha-1 Blocker; Benign Prostatic Hypertrophy Agent   Flomax   Tamsulosin   Benign prostatic hyperplasia   Oral Capsule: 0.4mg   Oral   Initial = 0.4mg QD, if no response after 2 to 4 weeks, may increase to 0.8mg QD Take 30min after same meal QD   N/A   Alpha-1 antagonist, selectively blocks sympathetic nervous stimulation of the receptor  relaxation of the smooth muscles of prostate, prostatic urethra and bladder neck for improvement in urine flow rate  
Anti-hypertensive; Erectile Dysfunction Agent; PDE5 Inhibitor   Cialis   Tadalafil   Erectile Dysfunction Benign prostatic hyperplasia; Pulmonary HTN   Oral Tablet: 2.5, 5, 10, 20mg   Oral   Varies ED: 2.5mg QD or 10mg 30min prior to sexual activity BPH: 5mg QD   N/A   PDE5 inhibitor  
Anti-hypertensive; Erectile Dysfunction Agent; PDE5 Inhibitor; Vasodilator   Viagra   Sildenafil   Erectile dysfunction; Pulmonary HTN (Revatio only)   Oral Tablet: 25, 50, 100mg (Another brand name = Revatio, available in IV Soln. 10mg/12.5ml)   Oral   25-100mg (50mg is usual dose) 1 hour prior to sexual activity; max of 1 dose per day   N/A   Inhibitor of cGMP specific PDE5 in smooth muscle where PDE5 is responsible for degradation of cGMP  
Bisphosphonate; Ca2+ Regulator   Actonel; Atelvia   Risedronate   Osteoporosis; Paget’s disease; postmenopausal osteoporosis   Oral Tablet: 5, 30, 35, 150mg; Delayed Release Tablet: (Atelvia) 35mg   Oral   Varies   N/A   Binds to bone hydroxyapatite, and at the cellular level, inhibits osteoclast activity, thereby modulating bone metabolism  
Bisphosphonate; Ca2+ Regulator   Boniva   Ibandronate   Postmenopausal osteoporosis   Oral Tablet: 150mg; IV Soln: 1mg/ml   Oral, IV   2.5mg QD or 150mg once a month; IV: 3mg infused over 15-30 seconds every 3 months   N/A   Inhibits osteoclast-mediated bone resorption and turnover leading to a net gain in bone mass  
Bisphosphonate; Ca2+ Regulator   Fosamax   Alendronate   Osteoporosis; Paget’s disease; postmenopausal osteoporosis   Oral Soln: 70mg/75ml; Oral Tablet: 5, 10, 35, 40, 70mg; Effervescent Tab: 70mg   Oral   Typically 70mg once a week   N/A   Binds to bone hydroxyapatite and inhibits osteoclast-mediated bone resorption  
Androgen; Endocrine-Metabolic Agent   Androderm (Patch); AndroGel (Gel); Delatestryl (IM); Depo-Testosterone(IM); Striant (Buccal); Testim (Gel); Testopel (Implant)   Testosterone   Hypogonadism, Delayed Male Puberty   Transdermal Patch (ER): 2mg/24hr, 4mg/24hr, Topical gel/jelly: 1 or 1.62%; Buccal patch (ER): 30mg; SubQ Implant: 75mg; IM Susp: 100mg/ml 200mg/ml   Topically, Buccal, IM   Varies   N/A Adolescent males 13+ (IM and Pellet)   Endogenous androgen responsible for normal growth & development of male sex organs  
Adrenal Glucocorticoid; Anti-inflammatory; Corticosteroid; Dental Agent; Endocrine-Metabolic Agent   Aristocort; Kenalog; Nasacort   Triamcinolone Acetonide   Acquired Hemolytic Anemia; allergic rhinitis; asthma; collagen disease; disorder of endocrine system, eye, GI tract, respiratory system, skin; ganglion & synovial cyst; inflammatory disorder of musculoskeletal system; leukemia; malignant lymphoma; MS;   Inj. Susp: 10mg/ml, 40mg/ml; mucous membrane paste 0.1%; nasal spray: 55mcg/spray; topical cream & ointment; 0.025, 0.1, 0.5%; topical lotion: 0.025, 0.1%; topical spray: 0.147mg/gm   Intra-articular, intralesional, IM, intravitreal, nasal, topical   Varies   Varies 2YO+ nasal (dental paste – not for children)   Synthetic corticosteroid with anti-inflammatory, antipruritic and antiallergic properties  
Monophasic Contraceptive Combo (Estrogen and Progestin)   Aviane; Alesse; Loestrin 24 Fe; Ortho Novum; Ovcon; Ovral; Ortho-Cept; Sprintec; Yasmin; Yaz;   Monophasic Contraceptive Combo   Contraception   Varies   Oral   1 tab QD, same time each day   Safety & efficacy before menarche have not been established   Suppresses gonadotropins; prevents ovulation and induces changes in the endometrium and cervical mucus to decrease the possibility of fertilization and implantation  
Monophasic Contraceptive Combo   Ortho Evra   Ethinyl Estradiol/ Norelgestromin   Contraception   Transdermal Patch (ER): 35mcg/24hr 150mcg/24hr   Transdermal   1 patch every week for 3 weeks, patch-free for week 4   Safety & efficacy before menarche have not been established   Suppresses gonadotropins; inhibits ovulation; changes cervical mucus and the endometrium  


   


 
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