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BLOCK 2

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Easily disseminated/transmitted person->person, high mortality -> public health impact, panic/social disruption, requires action for preparation   Category A (High priority)  
Moderate dissemination, Moderate/Low mortality, Requires increase in CDC diagnostic capacity, Considered Biological Weapons   Category B (Second priority)  
Easily available,easily produced/disseminated, potential high motality/morbidity/IMPACT, Preparedness requires ongoing research into detection,diagnosis, treatment, prevention   Category C (emerging organisms)  
Anthrax   A (inhalation)  
Botulism   A (inhalation)  
Plague   A  
Smallpox   A  
Tularemia   A  
Viral hemorrhagic fevers (Ebola, Marburg)   A  
Brucellosis (Brucella)   B  
Food safety threats (E. coli O157:H7)   B  
Q fever (Coxiella burnetii)   B  
Ricin toxin (Ricinus communis - castor beans)   B (percutaneous)  
Influenza   C  
SARS   C  
Multi-drug resistant tuberculosis   C  
Hantavirus   C  
Salmonella typhimurium   B (oral)  
gram + rod, soil w/ spores, farm handlers, cutaneous syndrome - skin papules form, rupture, and resolve, inhalation more serious (meningitis, shock)GI uncommon but serious (uncooked meat) vomiting + bloody diarrhea, fluid disreguated (edema, inflammation)   Bacillus antracis  
ds DNA virus, airborn, sometimes contact spread, incubation 12 days, red spots (enanthem) in mouth, macular rash on skin, micro- Guarnieri bodies in epithelium (pink cytoplasmic aggregates of virus), death unclear - many organs affected; pneumonia and cir   Variola major/minor (smallpox)  
Gram + rod, rodents,3 forms- pneumonic (cough, hemoptysis), septicemic (hypotension, delerium), bubonic (swollen lymph nodes), fatal w/o treatment or even with due to disseminated intravascular coagulation, endotoxic shock, pneumonia, meningitis   Yersinia pestis (plague)  
Gram - rod (highly infectious),(rabbit fever)contraction by handling dead bodies, ticks and flies (ulcers), inhalation (pneumonia)antibiotics effective   Francisella tularensis  
Gram + rod (product of Clostridium botulinum),improperly canned foods, infected wounds, inhibits ACh release (resp failure),Cellulits and gangrene if infected with live bacteriamicro- necrosis, bacteria, neutrophils   Botulinum toxin  
viral hemorrhagic fever, vascular damage then bleading, reservoir hosts or vectors transmit to humans, deer mice (Hantavirus) west coast,Evola, Marburg, Lassa (Africa)often fatal- disseminated intravascular coagulation   RNA viruses (viral hemorrhagic fever)  
Protein toxin in castor beans, blocks protein synthesis via ribosomes,diahrrea, organ damage, shock   Ricin  
Anthrax B-subunit   protective factor  
Anthrax A-subunit causing cellular water efflux by activating cAMP   Edema factor  
Anthrax A-subunit protease which destroys mitogen-activated protein kinase kinases   Lethal factor  
Lesion has necrosis, neutrophils and macrophages, large rectangular gram-positive extracellular bacteria in chains   Antrax  


   






 
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