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clinical med quiz

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
inhibits synthesis of vitamin K dependent clotting factors by the liver that stimulate prothrombin production   coumadin  
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activates antithrombin which indirectly blocks thrombin -made from pig or bovine mucosa   heparin  
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thrombin inhibitor, processed heparin, chemically consistent   lovenox  
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INDIRECTLY inhibits factor Xa   arixtra  
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DIRECTLY inhibit factor Xa   xarelto  
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direct thrombin inhibitor   pradaxa  
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prevent platelets from clumping together to form a clot by various mechanisms   antiplatelets  
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inhibits an enzyme that causes platelet clumping   aspirin (NSAIDS)  
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inhibits two enzymes that cause platelets to clump   aggrenox  
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used only in the hospital as part of combination therapy for acute coronary disease   monoclonal antibodies / glycoprotein inhibitors: ReoPro, Integrilin, Aggrastat  
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block ADP receptors on the platelet surface to prevent clumping   Thienopyridines: ticlid, plavix, effient  
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can cause coagulation disorders   Thienopyridines: ticlid, plavix, effient  
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plavix effect can be reduced by PPI's   Thienopyridines: ticlid, plavix, effient  
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dont dissolve clots dont thin blood   anticoagulants  
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work by interfering with the bodys ability to clot by reducing the activity of certain proteins (clotting factors)   anticoagulants  
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given to prevent clotting or treat existing clots by stabilizing them & preventing embolisms   anticoagulants  
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monitor PT & INR   coumadin  
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takes 96+ hrs for onset of action   coumadin  
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therapeutic ranges: 2-3 for most 2.5 -3.5 for higher risk (valves, MI)   coumadin  
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if > 4.0 high bleeding risk & no more therapeutic benefit   coumadin  
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given orally   coumadin & xarelto  
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reversed by vitamin K or fresh frozen plasma   coumadin  
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unpredictable blood levels & highly individual response   heparin  
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requires frequent monitoring of aPTT   heparin  
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risk of HIT when body form antibodies against, check platelets   heparin  
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given IV or SQ   heparin  
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reversed by protamine   heparin  
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MORE predictable plasma levels & therapeutic response   lovenox  
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longer half-life so can be given daily or BID   lovenox  
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monitoring PTTs is not needed or accurate   lovenox  
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given SQ   lovenox & arixtra & heparin  
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partially reversed by protamine   lovenox  
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predictable plasma levels & therapeutic response   arixtra & xarelto  
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do not require lab monitoring   arixtra & xarelto & lovenox  
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monitor platelets   arixtra & heparin  
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no antidote, may need dialysis   arixtra & pradaxa  
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has to be taken twice daily   pradaxa  
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no lab monitoring possible   pradaxa  
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dangerous due to no reversal agent & delayed recovery of normal clotting, wait it out   pradaxa  
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