Question | Answer |
Aripiprazole (Abilify) | Third generation |
clozapine (Cloziril) | Second generation |
olanzapine (Zyprexa) | Second generation |
paliperidone (Invega) | Second generation |
quetiapine (Seroquil) | Second generation |
resperidone (Risperdal) | Second generation |
ziprasdone (Geodon) | Second generation |
chlorpromazine (Thorazine) | First generation |
thioridazine (Mellaril) | First generation |
loxapine (loxitane) | First generation |
molindone (Moban) | First generation |
perphemazine (trilaphon) | First generation |
trifluoperazine | First generation |
thiothixene (Navene) | First generation |
fluphenazine (Prolixin) | First generation |
haloperidol (Haldol) | First generation |
pimozide (Orap) | First generation |
chlorpromazine (Thorazine)potency | Low potency |
thioridazine (Mellaril)potency | Low potency |
loxapine (loxitane)potency | Medium potency |
molindone (Moban)potency | Medium potency |
perphemazine (trilaphon)potency | Medium potency |
trifluoperazine potency | high potency |
thiothixene (Navene)potency | high potency |
fluphenazine (Prolixin)potency | high potency |
haloperidol (Haldol)potency | high potency |
pimozide (Orap)potency | high potency |
Low potency = | high sedation + high Ach + low EPS |
High potency = | low sedation + low Ach + high EPS |
anticholorinergic effects | blurred vision dry mouth decreased tearing dry nasal passages tachycardia constipation urinary hesitency |
pisa syndrome | leaning to one side elderly particularly susceptible |
EPS | dystonia, dyskinesia, akathisia, tardive dyskinesia |
antiadrenergic effects | hypotension postural hypotension tachycardia decreased cardiac output |
cardiac effects | longer qt interval fatal arrhytmias |
endocrine effects | amenorrhea, loss of labido, galactorrhea, inc risk osteoporosis impotence, gynecomastia, low sperm count, fiminazation |
metabolic syndrome | reduced metabolism glucose, resistance to insulin, DM2, obesity, inc lipid levels, hypertension, coagulation abnormalities |
Neuroleptic Malignant Syndrome | hypterpyrexia, muscular ridgity, tremors, alt conciousness, autonomic dysfux, HTN, tachycardia, tachypnea, diaphoresis, incontinence. Elev CPK, myglobinurea, elv WBC. Metabolic acidosis. |
Treatment for NMS | stop drug, administer bromocriptine mesylate (Parlodel), Dantrium, treat fever, maintain hydration, maintain vital fx |
pseudoparkinsonism | mask like, stiff/stoop posture, shuffling gait, drooling, tremor, pill rolling |
dystonia | contractions of tongue, face, neck, back, jaw |
akethesia | motor inner drive restlessness tapping foot, rocking foward/backward in chair, shifting weigh |
tardive dyskensia | protruding/rolling tongue, blowing, smaking, licking, spastic facial distortions. |