Question | Answer |
rosuvastatin (Crestor) | HMG CoA Reductase Inhibitors “Statins” |
atorvastatin (Lipitor) | HMG CoA Reductase Inhibitors “Statins” |
simvastatin (Zocor) | HMG CoA Reductase Inhibitors “Statins” |
pravastatin (Pravachol) | HMG CoA Reductase Inhibitors “Statins” |
lovastatin (Mevacor) | HMG CoA Reductase Inhibitors “Statins” |
fluvastatin (Lescol) | HMG CoA Reductase Inhibitors “Statins” |
pitavastatin (Livalo) | HMG CoA Reductase Inhibitors “Statins” |
cholestyramine (Questran) | Bile Acid Binding Resins |
colestipol (Colestid) | Bile Acid Binding Resins |
colesevelam (Welchol) | Bile Acid Binding Resins |
ezetimibe (Zetia) | Cholesterol Absorption Inhibitor |
ezetimibe/simvastatin (Vytorin) | Cholesterol Absorption Inhibitor |
gemfibrozil (Lopid) | Fibric Acid Derivatives |
fenofibrate (Tricor, Antara, Lipofen, Trilipix) | Fibric Acid Derivatives |
niacin (Niaspan-rx, otc’s) | Other Drugs |
omega-3-fatty acids (ethyl ester) (Lovaza) | Other Drugs |
Statins indications | Hypercholesterolemia & mixed hyperlipidemia |
statins adverse effects | GI (constipation, diarrhea, heartburn, abdominal cramps)
Liver enzyme elevation & hepatitis
Rhabdomyolysis |
Bile Acid-binding Resins indications | Hypercholesterolemia, pruritis, & diarrhea |
Bile acid-binding resins adverse effects | constipation, fecal impaction, and rash |
niacin adverse effects | gastric irrigation, glucose intolerance, myalgia, rhabdomyolysis, myopathies, vasodilation, flusing, prutitus |
Fibric acid derivatives adverse effects | allergic reactions, blood cell deficiencies, myalgia, rhabdomyolysis and other myopathies |
rhabdomyolysis is | fatal form of skeletal muscle toxicity (myopathy) |
etimibide (Zetia)
ezetimibide/simvastatin
indications | Hypercholesterolemia |
cholesteron absorption inhibitors:
etimibide (Zetia)
ezetimibide/simvastatin
adverse effects | Headache
Myalgia |
niacin indications | Mixed hyperlipidemia
HDL deficiency |
anticoagulant drugs indications | Patients who have had HIT
Unstable angina
Acute MI |
anticoagulant drugs adverse effects | Vasodilation, pruritis (itching), & flushing
Hepatitis
GI
Hyperglycemia |
omega-3 fatty acids | lower triglyceride levels, improve LDL-c to HDL-C ratio |
Fibric acid derivatives
gemfibrozil (Lopid)
fenofibrate (Tricor)
indications | Hypertriglyceridemia
Mixed hyperlipidemia |
Fibric acid derivatives
gemfibrozil (Lopid)
fenofibrate (Tricor)
contraindication | avoid with statins |
Fibric acid derivatives moa | Decrease VLDL & LDL while raising HDL |
drug to increase HLD | niacin |
niacin contraindicated with | pt with diabetes |
Bile Acid-binding Resins moa | Binds with bile acids to prevent recycling which makes the liver produce more from the cholesterol , reduce cholesterol LDL |