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CJD/vCJD TTI

CJD and blood transfusion safety

QuestionAnswer
Clinical course of patients diagnosed with CJD or CJD uniformly fatal, and no treatment is available
Describe effect of pathogen reduction technologies on vCJD risk None
Routes of transmission for vCJD food-borne (Mad cow disease) and transfusion
This mutation of the PRNP gene is common in transfusion transmitted cases of vCJD 129MM (methionine homozygous at codon 129 (129MM) of the PRNP gene)
Number of documented cases of sporadic CJD transmitted by transfusion None
Two countries with the most vCJD cases UK and France (89% of cases; 215 cases of 241 total cases)
All 4 blood transfusion related cases of vCJD were from these products non-leukoreduced RBCs
How many cases of transfusion transmitted vCJD have been reported outside of the UK?
Created by: jfshikle