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Adult Medicine

Hematology-Iron Deficiency

1. when does iron deficiency anemia occur? When the body lacks iron to produce the hgb it needs to make RBC
2. what are the etiologies of Fe deficiency? Increased requirements, inadequate dietary intake, decreased intestinal absorption, blood loss, parasitic infestations, bleeding disorders, excessive menstrual blood loss
3. The most important causes of microcytic anemia? Fe deficiency, hemoglobinopathies such as thalassemia, the anemia of chronic disease
4. What are the symptoms of microcytic anemias? Weakness, fatigue, lassitude, palpitations, lightheadedness, pica, other
5. What are the signs of microcytic anemias? Pallor, tachycardia, murmur, nail changes (koilonychia), mouth and tongue abnormalities (cheilitis, glossitis), achlorhydria, and gastric atrophy
6. What are the labs for Fe anemia? Serum ferritin, serum Fe, TIBC, MCV, MCH, MCHC, RBCs, microcytic/hypochromic, poikilocytes if severe
7. What are the lab values for Fe deficiency? Serum Fe low, transferrin high, ferritin low
8. What are the lab values of anemia of chronic disease? Serum Fe low, transferrin is not increased, ferritin is normal, reticulocyte normal may increase after blood loss, platelet count normal or elevated, late normoblasts have scanty cytoplasm
9. What is the gold standard for Fe deficiency diagnosis? Bone marrow aspirate, but rarely necessary
10. What is the treatment for Fe? Ferrous iron, Iron dextran, Transfusion
11. What are the differential diagnosis for Fe deficiency? Thalassemia, anemia of chronic infection, sideroblastic anemia
Created by: sap_213