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Flap 1 Flap 2
Gram - Spirochetes  Borrelia burgdorferi, Treponema pallidum, Leptospirosis interrogans  
Borrelia burgdorferi: Labs  Lyme Serology- EIA and Western Blot  
Borrelia burgdorferi: Toxins  Lipid A/LOS, OspA--> OspC  
Borrelia burgdorferi: Acute Disease  Fever, Bull's eye rash, Myalgias and arthralgias, Meningeal irritation  
Borrelia burgdorferi: Chronic Disease  Meningoencphalitis, myocarditits, and disabling recurrent arthritis  
Borrelia burgdorferi: Disease  Lyme Disease  
Borrelia burgdorferi: Treatment  Oral doxycycline, ceftriaxone, amoxicillin, or erythromycin  
Treponema pallidum: Labs  Microaerophilic, Dark field immunoflourescent microscopy, RPR, VDRL  
Treponema pallidum: Toxins  Endotoxins, Hyaluronidase  
Treponema pallidum: Primary disease  Painless chancre that is contagious  
Treponema pallidum: Secondary disease  headache, Maculo-papular centripetal rashes, Arthralgias  
Treponema pallidum: Latent disease  Condyloma lata appear with recurrences  
Treponema pallidum: Congenital disease  Transplacental transmission  
Treponema pallidum: Tertiary disease  Neurosyphilis, Gummatous, and Cardiovascular disease  
Treponema pallidum: Treatment  Benzathine Penicillin, Pen G, Doxycycline  
Leptospira interrogans: Labs  Obligate aerobe  
Leptospira interrogans: Toxins  Endotoxins, Hyaluronidase  
Leptospira interrogans: Acute disease  Flu-like febrile illness with bacteremia  
Leptospira interrogans: Recurrent disease  Fever, Aseptic meningitis  
Leptospira interrogans: Treatment  Penicillin G, Doxycycline, Ceftriaxone  
Leptospira interrogans: Transmission  Zoonotic transmission  

 
 
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