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autonomic pharm Word Search Puzzle

Question	Answer
alpha-1	Gq; increaes vasculr smooth muscle contraction
alpha-2	Gi; decrease sym outflow; decrease insuline release
beta-1	Gs; heart- increase HR, contractility; increase renin release, increase lipolysis, maintains aqueous humor formation
beta-2	Gs; lungs- vasodilation, bronchodilation; heart- increase HR, contractility; increase lipolysis, increase glucagon release
M1	Gq; in brain; CNS, enteric nervous system
M2	Gi; decrease HR, contractility
M3	Gq; increase exocrinie gland secretions, increase gut peristalsis, increase bladder contraction
D1	Gs; relaxes renal vascular smooth muscle
D2	Gi; modulates transmitter release, especially in brain
H1	Gq; increase nasal and bronchial mucus production, contraction of bronchioles, pruritis, pain
H2	Gs; increase gastric acid secretion
V1	Gq; increase vascular smooth muscle contraction
V2	Gs; increase water permeability and reabsorption in the collecting tubles of kidney
Gq receptors	H1, alpha-1, V1, M1, M3 (HAVe 1 M&M)
Gs receptors	B1, B2, D1, H2, V2
Gi receptors	M2, alpha-2, D2 (MAD 2's)
Gq protein MOA	PLC --> PIP2 --> IP3 and DAG --> increase Ca++ in and PKC
Gs protein MOA	adenylyl cyclase --> cAMP --> PKA
Gi protein MOA	inhib adenylate cyclase -->decreased cAMP --> inhib PKA
bethanechol	direct ACh agonist; activates bowel and bladder
carbachol	direct ACh agonist; used in glaucoma, pupillary contraction, release of intraocular pressure
pilocarpine	direct ACh agonist; stimulates sweat, tears, saliva
methacholine	direct ACh agonist; challenge test for asthma diagnosis
neostigmine	AChE inhibitor; reversal of neuromuscular jxn blockade, MG; NO CNS penetration
pyridostigmine	AChE inhibitor; MG (long-acting)
edorphonium	AChE inhibitor; tensilon test to diagnose MG
physostigmine	AChE inhibitor; glaucoma
used in glaucoma; crosses BBB; used to treat atropine OD	physostigmine
AChE inhibitor poisoning	excess ACh; DUMBBELSS- diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, salivation
AChE inhibitor OD antidote	atropine (anti-muscarinic), parlidoxime (regenerates active AChE)
AChE inhibitor for Alzheimer's	donepezil, galantamine, rivastigmine
muscarinic antag; produces mydriasis and cycloplegia	atropine
muscarinic antag; use in Parkinson's	benztropine
muscarinic antag; use for motion sickness	scopolamine
muscarinic antag; used in asthma, COPD	ipratropium
muscarinic antag; use to reduce urgency in mild cystitis and reduce bladder spasms	oxybutynin
muscarinic antag; use for peptic ulcer treatment	propantheline, methoscopolamine, glycopyrrolate
glaucoma drugs	alpha-agonists (epi, brimonidine), beta-blockers (timolol), cholinergics (pilocarpine), diuretics (acetazolamide, mannitol), PG (latanoprost)
1st line for glaucoma	latanoprost (PG)
glaucoma drug that increases outflow of aqueous humor	pilocarpine
atropine contraindications	glaucoma, BPH, GI obstruction, dementia, infants with fever
atropine	muscarinic antag; (blocks ACh effects); used to treat cholinesterase inhibitor poisoning (insecticides)
parathion	AChE inhibitor in insecticides --> HIGH amounts of ACh; get DUMBBELS
effects of atropine	muscarinic antag --> decreased ACh effects; increased temp, decrease secretions, peripheral vasodilation, mydriasis, agitation, urinary retention, constipation
hexamethonium	nicotinic antag; blocks both sym and parasym; prevents reflex bradycardia caused by NE
epi	alpha-1, alpha-2, beta-1, beta-2 sympathomimetic
NE	alpha-1, alpha-2 > beta-1 sympathomimetic
isoproterenol	beta-1 = beta-2 sympathomimetic
dopamine	D1 = D2 > B > alpha sympathomimetic
dobutamine	beta-1 > beta-2 sympathomimetic
phenylephrine	alpha-1 > alpha-2 sympathomimetic
albuterol	beta-2 > beta-1 sympathomimetic
terbutaline	beta-2 > beta-1 sympathomimetic
ritodrine	beta-2 sympathomimetic
amphetamine	indirect general agonist; releases stored catecholamines
ephedrine	indirect general agonist; release stored catecholamines
cocaine	indirect general agonist; uptake inhibitor
clonidine	central alpha-2 agonist
methyldopa	central alpha-2 agonist
treatment for anaphylaxis, open angle glaucoma	epi
treatment for septic shock	NE
treatment for shock, heart failure	dopamine
treatment for cardiogenic shock	dobutamine
treatement for acute asthma	albuterol
treatement for reducing premature uterine contractions	terbutaline, ritodrine
treatement for narcolepsy, obesity, ADD, MDD	amphetamine
treatment for nasal congestion, urinary incontinence, hypoTN	ephedrine
causes vasoconstriction and local anesthesia	cocaine
treatment for HTN, especially in patients with renal disease	clonidine, methyldopa
phenoxybenamine	irreversible alpha blocker
phentolamine	reversible alpha blocker
used to treat pheochromocytoma	phenoxybenzamine (irreversible alpha block), phentolamine (reversible alpha block)
SE: 1st dose orthostatic hypoTN	prazosin (alpha-1 blocker)
prazosin, terzosin, doxzosin	alpha-1 blocker
use to treat HTN, urinary retention in BPH	prazosin (alpha-1 blocker)
mirtazapine	alpha-2 blocker
use for thin, elderly patient with depression	mirtazapine (anti-depressant, alpha-2 blocker)