| Question | Answer |
| Dz associated w/ anti-acetylcholine receptor? | myasthemia gravis |
| Dz assoc. w/ anti-centromere Ab? | CREST Sx 60% and PSS 10% |
| Dz assoc. w/ anti-gliadin Ab? | Celiac Dz (95%) |
| Dz assoc. w/ anti-glomerular basement membrane? | Goodpasture Sx (90%) |
| Against what Ab is anti-GBM directed to? | Collagen Type IV |
| What Dz is assoc. w/ anti-islet cel Abs? | Type I DM |
| What Dz is assoc. w/ anti-microsomal Abs? | Hashimotos (97%) autoimmune hepatitis (70%) |
| Dz. assoc. w/ anti-mitochondrial Abs? | primary biliary cirrhosis (90-100%) |
| Dz. assoc w/ C-ANCA? | Wegner's Granulnomatosis |
| Dz. assoc. w/ P-ANCA? | Polyarteritis Nodosa (PAN) and Hep B associated to PAN |
| Dz. assoc. w/ anti-parietal cell Abs? | Pernicious Anemia |
| Dz. assoc. w/ intrinsic factor Abs? | Pernicous Anemia Type I (Ab to B12 prevent binding to IF) Type II (Ab to IF or complex) |
| Dz. assoc. w/ anti-smooth muscle Abs? | Autoimmune Hepatitis (70%) |
| Dz. assoc. w/ anti-thyroglobulin Ab? | Hashimoto (85%) Grave's (30%) |
| What Dz is associated w/ myasthemia gravis? | thymoma (60%) |
| HLA relationship of hemochromatosis? | A3 |
| HLA relationship of Myasthemia Gravis? | B8 |
| HLA relationship of Celiac Dz? | B8 and DR3 |
| HLA relationship of Ankylosing Spondylitis? | B27 |
| HLA relationship of Multiple Sclerosis? | DR2 |
| HLA relationship of Type I DM? | DR3 and DR4 |
| HLA relationship of Rheumatoid Arthritis? | DR4 |
| What is the MCC of Autoimmune Hemolytic Anemia? | Warm IgG Lupus |
| 2nd MCC of Hemolytic Anemia? | Drug Induced Hemolytic Anemia |
| What two drugs used for HT for pregnancy? | Hydralazine, Methyl-Dopa |
| Hydralazine causes? | Drug Induced Lupus |
| MC drug that causes drug-induced Lupus? | Procainamide |
| What Ab is made against alpha-methyl dopa? | IgG G is for Gravida |
| What Ab is made against Quinide? | IgM |
| What does IgG activate? | Macrophages to become active |
| What does IgM activate? | Complement System MAC C1-C9 |
| What disease causes leukemoid reaction? | B. pertussis Scares Pediatricians!!! >60,000 WBCs |
| Mononucleosis caused by ------> | EBV |
| What cell does EBV infect? | B-Cell |
| What is the marker (receptor) for EBV, B-cells? | CD21 |
| What drug induces atypical lymphocytes? | phenytoin |
| MOA of Phenytoin? | Blocks intestinal Conjugase |
| What drug causes macrocytic anemia and atypycal lymph? | Phenytoin |
| Where does EBV hide for the rest of the life of the patient? | Salivary Glands Kissing Disease |
| What test is diagnostic for Mononucleosis? | Anti Heterophile Antibody |
| What diseases cause eosinophilia? | Strongyloides Malaria Type I Yes whipworm |
| MCC of Bud-Chiari Sx? | polycytemia vera |
| Age of ALL? | 0-15 |
| Age of AML? | 15-40 40-60 |
| Age of CLL? | >60 |
| Age of CML? | 40-60 |
| MC overall Leukemia? -------> | CLL |
| Characteristic of CLL? | MC generalized non-tender lymphadenopathy >60y ? |
| MC Leukemia >60yo? | CLL |
| Where does CLL metastisize to? | lymph nodes |
| 49 y.o. 150,000 WBC 1% myeloblasts (<30% blasts) generalized lymphadenopathy | CML |
| Translocation of CML? | t9;22 of abl gene |
| 49 y.o. 150,000 WBC 1% myeloblasts (<30%) generalized lymphadenopathy | CML |
| What gene/chromosome is important in CML? | Philadelphia Chromosome 22 |
| What translocation is seen in CML? | t9;22 |
| What is the gene in t9;22? | bcr-abl gene |
| What two tests are used to Dx CML? | Philadelphia Chromosome (+) and LAP (low level) LAP = leukocyte alkaline phosphatase not absorbed by malignant cells |
| What do is the Dx when you see a tear drop cell? | Agnogenic Myeloid Metaplasia |
| Pt. 4yo, w/ generalized non-tender lymphadenopathy, sternal tenderness, hepatosplenomegaly, fever, normocytic anemia, 50,000 WBCs abnormal appearing cells | ALL |
| What antigen is use to detect ALL? | CALLA |
| What does CALLA detect? | B-cells CD10 |
| Pt. 65 yo man, hepatosplenomegalic, 90,000 WBC smudge cells, also pt. has hypogammaglobulinemia | CLL age gives it away |
| What leukemia has auer rods in it? | AML |
| What leukemia has lots of auer rods? | Acute Promyelocytic Leukemia (M3) |
| What are the four/five myeloproliferative dz? | 1. polycythemia vera 2. chronic myelogenous leukemia 3. adenogenic myeloid metaplasia 4. essential thrombocytemia myelodysplastic Sx |
| What are the four H's of polycythemia vera? | 1) Hyperviscosity 2) Hypervolemia 3) Histaminemia 4) Hyperuricemia |
| What is the Dx of a patient that complains of itching after taking a shower hot or cold? | Polycythemia ruba vera |
| What is the translocation of Burkitt's Lymphoma? | t8;14 |
| What is responsible for Burkitt's Lymphoma? | EBV |
| What do you see in the pathology slides for Burkitt's? | Starry Sky Appearance |
| What are the three K for Burkitt's? | Kid 8yo 8 is for translocation 8;14 blacK C-Myc |
| What are the stars in Burkitt's? | Macrophages |
| United States where is Burkitt's Located? | Abdomen (Peyer's Patches, Paraortic Lymph nodes), Testicle also |
| African Burkitt's lymphoma MC location? | Jaw |
| What two tissues are resistant to cancer infection? | Cartilage and Elastic Vessels |
| Pat. w/ plaque like lesions w/ inflamatory cells in epidermis? | Neoplastic epidermis cells Helper T-Cells Mycosis Fungoides |
| What is a helper T-cell malignancy that involves skin? | Mycosis Fungoides |
| What cell is involved in Mycosis Fungoides? | Sezary Body |
| What is a sezary body? | Helper T-cell seen in plasma of pat. w/ Mycosis Fungoides |
| What substance is secreted and produced by Gastic Adenocarcinoma (Linitis Plastica)? | Mucin Producer |
| What is the appearance of the stomach in linitis plastica? | diffusely inflitrative (thickened appearance) mucosa and muscularis produced rigid thick, leather-bottle gastric wall |