Generation
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| Question |
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| Answer |
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| What is the definition of Threshold Stimulation? |
the minimum DEPOLARIZATION required to trigger a Na+ permeability change --> AP |
| What is the definitions of Subthreshold? |
Insufficient DEPOLARIAZATION for a response |
| T/F The lower the amplitude of an AP the less likely it is to reach the synapse. |
F. All-or-None Principle - AP attains FULL amplitude (30mv at 1ms) or it does not occur |
| What is Hyperpolarization? |
MORE negative RP --> decreased membrane excitability |
| What are some of the causes of Hyperpolarization? |
1. INTERFERENCE with Na+ INFLUX; 2. INCREASED Extracellular Ca++
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| What medicine causes Hyperpolarization and what is its function? |
Lidocaine - interference with Na+ INFLUX - anesthesia |
| What is Depolarization? |
LESS negative RP --> INCREASED membrane Excitability |
| What are some causes of Depolarization? |
1. ENHANCEMENT of Na+ INFLUX; 2. DECREASED Extracellular Ca++ |
| What is Paresthesia? |
Increased membrane permeability |
| What is a side effect of Paresthesia? |
Abnormal Sensation, Hallucination, Hearing Things, Schizo |
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