KTC-Epinephrine
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| EPINEPHRINE's Trade Name | (ADRENALINE)
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| CLASS: | Sympathomimetic
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| Description: | Epinephrine is a naturally occurring catecholamine that increases heart rate, cardiac contractile force, myocardial electrical activity, systemic vascular resistance, through bronchial artery constriction can reduce pulmonary congestion
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| Onset/Duration: | Depends on route; 3-5 minutes
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| Beta 1 Sympathetic actions | May restore electrical activity in asystole, Increase myocardial contractility, Lowers threshold for defibrillation
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| Beta 2 sympathetic actions | Acts as a bronchodilator
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| Alpha sympathetic actions | Produces vasoconstriction improving coronary blood flow, Vasoconstriction help support blood pressure in anaphylactic shock
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| Indications for Cardiac Arrest: | Includes: V-Fib, V-Tach without pulse, PEA, Asystole
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| Would use for Profound Bradycardia AFTER | atropine in the adult patient
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| Indications for Acute Allergic Reactions | Mild or severe anaphylactic reaction or bronchoconstriction(severe asthma) usually pediatric patient
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| Contraindications: | Hypersensitivity to sympathomimetic amines/ During labor/ Narrow angle glaucoma/hypertension/coronary insufficiency hemorrhagic traumatic or cardiac shock
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| Adverse Reactions: | Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina
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| Dosage/Route: | Cardiac Arrest(PEA, Asystole, V-Fib, pulseless V-tach), 1mg of 1:10,000 solution IV every 3-5 minutes, 2 to 2 ½ times the amount if given down ETT
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| Anaphylactic Reaction Dosages: | Mild: 0.3-0.5mg (1:1000) subcutaneous, Severe: 0.3-0.5mg 1:10,000) slow IV, Drip dosage: Mix 1mg in 500ml of D5W or NS 2mcg/ml; run at 1-2mcg/min; profound bradycardia (titrate to response 2-10mcg/min)
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| Drug interactions: | potentiates other sympathomemetics and MAOI's; Deactivated by alkaline solutions(sodim bicarb, furosemide)
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