ARB's
Help!
|
|
||||
|---|---|---|---|---|---|
| Mechanism | Block binding of angiotensin II to receptors.
Prevent vasoconstriction and aldosterone release.
AT1 receptor mediates above
AT2 may have anti – proliferative and vasodilatory effects.
No effect on bradykinin pathway.
🗑
|
||||
| Kinetics | High first pass effect.
Highly protein bound.
Renal and hepatic elimination.
Telmisartan almost exclusively hepatic.
🗑
|
||||
| Side effects | Same as ACE inhibitors but without the cough.
🗑
|
||||
| Drug Interactions | Telmisartan with other hepatically cleared drugs.
Increased digoxin and warfarin levels.
Potassium-sparing diuretics and potassium supplements.
🗑
|
||||
| Names | Losartan (Cozaar).
Candesartan (Atacand).
Eprosartan (Teveten).
Irbesartan (Avapro).
Telmisartan (Micardis).
Valsartan (Diovan).
Eprosartan (Teveten).
Olmesartan (Benicar).
Also in combination with thiazides and other antihypertensives.
🗑
|
||||
| Aliskiren (Tekturna) | Mechanism of action:
Direct renin inhibitor
Kinetics:
Poor oral absorption
Decreased by high – fat meal
CYP3A4 metabolism
Excreted in urine and feces,
Adverse effects
Hyperkalemia
Hypotension
Drug interactions
CYP
May decrease effect of furose
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
DianaB
Popular Pharmacology sets