Block 7 - immuno words and such from packet 2
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| B Cell receptor | the cell surface-located receptor for antigen on B cell
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| T cell receptor (TCR) | the receptor for antigen on T lymphocytes
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| Histocompatibility Molecule | glycoproteins on surface of cells. Responsible for the compatibility, or lack of it,in tissues of genetically different individuals.
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| CD4 | on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity.
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| T-helper cells | T cells with CD4 attached - assist responsiveness of other cells
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| CD8 | on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity.
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| T-cell with CD8 | Killing function = lyse virally infected cells
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| cytotoxic T lymphocyte (CTL) | another name for T-cell with CD8
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| CD3 | necessary for a signal to be transduced to the cytoplasm after the TCR binds antigen, thus allowing T-cell activation
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| Fc receptor in phagocyte surface membrane | fraction crystallizable: does not bind antigen, but activates a molecular pathway known as complement and has ability to bind receptors found on macrophages and other cells - so increases likelihood of opsonization
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| Immune complex | lattice of antibody and antigen formed in body
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| 3 different complement pathways | classical, lectin, alternative
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| mannose binding lectin pathway | recognizes molecules containing mannose on the surface of bacteria and activates complement cascade
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| Toll-like receptor (TLR) + phagocytic cell | function like pattern recognition molecules to act as pathogen specific molecules such as lipopolysaccharide. binding causes the TLR produce and send signals - cytokines - that alert antigen specific lymphocytes
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| Pattern recognition molecules (PRM) | molecules of the innate immune system capable of recognizing molecules characteric of infection, for example, double-stranded RNA and some sugars
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| Interleukins 1 | protein produced by various cells, including macrophages, interleukin-1 raises body temperature, spurs the production of interferon, and stimulates growth of disease-fighting cells, among other functions. Abbreviated IL-1.
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| Interleukin 6 | IL-6: immune protein,monomer of 184 a.a. produced by T-cells, macrophages, and endothelial cells. Released in response to infection, burns, trauma, and neoplasia, functions: acute-phase protein induction to B- and T- cell growth and differentiation.
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| Interleukin 8 | A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. Released by monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 related to platelet factor 4.
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| Tumor Necrosis Factor | Tumor necrosis factor, cytokine produced by monocytes & macrophages. found in synovial cells and macrophages in the tissues. shares properties with interleukin 1. Stimulates IL1 and GM-CSF. Increases tissue damage by IL1.
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El Diablo 7
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