Microbiology - Prions, Viroids, Viruses
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| Prions, Viroids, Viruses | missing link btwn non-living & living b/c don't have all characteristics of living; lack ability to reproduce on their own; are infectious agents & reproduce inside host cells; obligate intracellular parasite
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| Prions | proteins, smallest disease agent; linked to Creutzfeld-Jakob Disease (mental degeneration), Kuru-Canabalism; Bovine Spongiferous Encephalitis (Mad Cow Disease); Scrapie (Sheep Disease)
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| Prions | Creutzfeld-Jakob Disease
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| Creutzfeld-Jakob Disease | Mental Degeneration
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| Prions | Kuru
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| Kuru | Cannibalism
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| Prions | Bovine Spongiferous Encephalitis
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| Bovine Spongiferous Encephalitis | Mad Cow Disease
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| Prions | Scrapie
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| Scrapie | Sheep Disease
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| Prusiner | 1997 Nobel prize - Scrapie
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| Viroid | made up of RNA; causes only plant diseases
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| Viruses | made up of at least capside (protien) & 1 of 4 kinds of Nucleic Acid
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| 4 kinds of Nucleic Acid | Double Stranded DNA & RNA, Single Stranded DNA &RNA
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| Viruses | some contain envelope
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| Viruses | Are genetic parasites
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| Genetic parasites | Depend on host metabolism for reproduction
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| Polio virus | only virus capable of reproduction w/o intact host cells
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| Venter | 2003; synthesized 'A' phage (bacterial virus)
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| Smallest Virus | Enteroviruses 30nm
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| Largest virus | Orthopox 300nm
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| Shape of Viruses | Helical, polyhedral - iscosa hedral, Complex - bullet shaped; Spherical - enveloped
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| 1st virus to be indentified | Tobacco Mosaic Virus (TMV)
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| TMV | filterable agent
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| Beijerinck (1899) | characterized them as infectious
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| Stanley (1935) | crystallized TMV; 1st observed virus TMV
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| viral replication | lytic & lysogenic cycles in phages
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