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Microbiology - Prions, Viroids, Viruses

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Prions, Viroids, Viruses   missing link btwn non-living & living b/c don't have all characteristics of living; lack ability to reproduce on their own; are infectious agents & reproduce inside host cells; obligate intracellular parasite  
Prions   proteins, smallest disease agent; linked to Creutzfeld-Jakob Disease (mental degeneration), Kuru-Canabalism; Bovine Spongiferous Encephalitis (Mad Cow Disease); Scrapie (Sheep Disease)  
Prions   Creutzfeld-Jakob Disease  
Creutzfeld-Jakob Disease   Mental Degeneration  
Prions   Kuru  
Kuru   Cannibalism  
Prions   Bovine Spongiferous Encephalitis  
Bovine Spongiferous Encephalitis   Mad Cow Disease  
Prions   Scrapie  
Scrapie   Sheep Disease  
Prusiner   1997 Nobel prize - Scrapie  
Viroid   made up of RNA; causes only plant diseases  
Viruses   made up of at least capside (protien) & 1 of 4 kinds of Nucleic Acid  
4 kinds of Nucleic Acid   Double Stranded DNA & RNA, Single Stranded DNA &RNA  
Viruses   some contain envelope  
Viruses   Are genetic parasites  
Genetic parasites   Depend on host metabolism for reproduction  
Polio virus   only virus capable of reproduction w/o intact host cells  
Venter   2003; synthesized 'A' phage (bacterial virus)  
Smallest Virus   Enteroviruses 30nm  
Largest virus   Orthopox 300nm  
Shape of Viruses   Helical, polyhedral - iscosa hedral, Complex - bullet shaped; Spherical - enveloped  
1st virus to be indentified   Tobacco Mosaic Virus (TMV)  
TMV   filterable agent  
Beijerinck (1899)   characterized them as infectious  
Stanley (1935)   crystallized TMV; 1st observed virus TMV  
viral replication   lytic & lysogenic cycles in phages  


   


 

 

 
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Created by: JYarger on 2006-03-09




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