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Parkinson's Disease drugs

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Drug
Description
MPTP   Meperidine derivative used to produce Parkinsonism in lab animals  
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Benztropine mesylate (Cogentin) Trihexyphenidyl HCl (Artane) Diphenhydramine (Benadryl)   Anticholinergic agents used in treatment of Parkinson's  
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Levodopa   Dopamine precursor, converted by dopa decarboxylase in CNS  
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Carbidopa   Frequently co-administered with Levodopa (Sinemet, Sinemet CR), inhibits peripheral dopa decarboxylase  
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Bromocriptine mesylate (Parlodel)   Full D2, and partial D1 agonist, ergot alkaloid  
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Apomorphine (Apokyn)   Dopaminergic agonist, may be neuroprotetive, can rapidly rescue Parkinson's patients from "frozen" state  
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Cabergoline (Dostinex)   Long-acting dopamine receptor agonist, ergot alkaloid, high affinity for D2 receptors, used clinically to decrease elevated prolactin levels (which may lead to menstrual changes, unwanted lactation in women, impotence in men)  
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Pramipexole dihydrochloride (Mirapex)   Dopaminergic agonist, more active at D3, versus D2 receptors, not an ergot alkaloid, may cause hallucinations  
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Ropinirole hydrochloride (Requip)   Dopaminergic agonist, more active at D3, versus D2 receptors, not an ergot alkaloid, metabolized by CYP1A2, also used to treat restless leg syndrome  
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Rotigotine (Neupro)   First transdermal synthetic dopaminergic agonist for Parkinsonism, more affinity for D1 receptors, but affects D2 as well  
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Amantadine HCl (Symmetrel)   Initially used as an antiviral, increases dopamine release in the brain  
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Selegiline HCl (Eldepryl), also known as deprenyl   Inhibits reuptake of dopamine in the CNS, selective irreversible inhibitor of MAO-B and MAO-A at higher doses, metabolites (amphetamines) may cause anxiety and insomnia  
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Rasagiline (Azilect)   Selective irreversible MAO-B inhibitor, neuroprotective and antiapoptotic activity (may slow the rate of neuronal deterioration), no amphetamine metabolites to cause side effects  
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Tolcapone (Tasmar)   Selective peripheral COMT inhibitor, prevents "wearing off" phenomenon of levodopa therapy, and interference of carbidopa metabolite with levodopa uptake into CNS, rarely used because it can cause serious liver disease  
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Entacapone (Comtan)   Selective peripheral COMT inhibitor, similar to tolcapone, may be affected by drugs that interfere with biliary excretion, glucuronidation, and/or intestinal beta-glucuronidase  
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