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90% rule click and move

        Help!  

Question
Answer
Rare diseases acct for what % in the real world?   1-3%  
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Autosomal Dominant (AD)diseases are usually what type of disorder 90% of the time?   Problem dealing with STRUCTURE of something  
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Autosomal Recessive (AR) diseases are usually what type of disorder 90% of the time?   Problem dealing with an ENZYME deficiency  
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Examples of AD diseases are?    
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Examples of AR diseases are?    
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What genetic disorders should we concerned about on boards 90% of the time when dealing with karyotypes?   13,18, 21 and sex linked disorders  
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Trisomy 13 is also known as (aka)?   Patau Syndrome  
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Trisomy 13 presents how?   Polydactyly, Microphthalmia, cleft lip and palate, MR  
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Trisomy 18 is aka?   Edward's Syndrome  
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Trisomy 18 presents how?   Duodenal atresia, Micrognathia, Rocker bottom feet, 2nd & 3rd digits overlap 4th, MR  
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Trisomy 21 is aka as Downs Syndrome, it presents how?   iris-brushfield spots Simian crease, epicanthal folds, large tongue, MR  
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Down's patients are at risk for what problems?   Cushing defects in the heart Acute leukemia Alzheimers in older patients  
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Down's and genetics, where is the problem?   90% is trisomy 21 usually d/t maternal age aka non-disjunction or can be Robertsonian translocation 14 to 21.  
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45 XO (monosomy of X chromo)   Turner's absent barr body always female or almost a female.  
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45 XO present with   cystic hygromas in the neck =webbed neck Widely spaced nipples-"nipples out to here"...Wolf. Short. Ammenorhea and lack of sexual maturity Big clue: Coarctation-BP high upper extr. low to NL in low extremity.  
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  Klinefelters  
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  Kallman's  
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