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Pap Smear, Colposcopy/endometrial biopsy

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Question
Answer
2nd most common cancer worldwide   cervical cancer  
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Highest incidence of cervical cancer in women ages   20-50  
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Prevalence of HPV infection in ages 14-59   26%  
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____% of women get HPV 2 years after first sex   50%. Usually transient, rarely lifelong  
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How to prevent HPV infection   avoid smoking, use condoms, limit partners, vaccine  
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How often is a pap smear reocommended according to USPSTF?   at least every 3 years. Start at age 21 or within 3 years of sexual debut  
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Where should you sample a cervix?   At the white border where squamous and columnar cells meet = squamocolumnar junction. This is where cancer most often occurs  
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Organisms on a pap   yeast, bacterial vaginosis, Trichomonas  
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ASCUS   Atypical Squamous Cells of Undetermined Significance (something is wrong but we don't know what it is)  
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LSIL   Low grade squamous intraepithelial lesion  
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HSIL   high grade squamous intraepithelial lesion  
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AGC   Atypical Glandular Cells (this is the most worrisome pap; can't see this with the naked eye, need to ask about hx of bleeding)  
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Interpretation of Pap results depends on   the age of the woman  
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In an adolescent woman with ASC-US or LSIL the next step is   to repeat cytology in 12 months. If then the woman has > or equal to HSIL, get a colposcopy. If less than HSIL, repeat cytology in 12 months  
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In an adolescent woman with HSIL who is - for CIN 2,3 the next step is   Observation with Colposcopy and Cytology every 6 months for up to 2 years. A high grade Colpscopy lesion or HSIL that persists for 1 year should then be biopsied  
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Management of women with ASCUS   Repeat cytology at 6months, Colposcopy, HPV DNA Testing  
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ASC-H   Atypical Squamous Cells cannot rule out High Grade dysplasia. (note: pap smears are not diagnostic, they are screening tests and 80% of the time are appropriate)  
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Pregnant women with low-grade Squamous Intraepithelial Lesion (LSIL)   Colposcopy or Defer Colposcopy. Don't brush or currettage the endocervix in pregnancy  
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Management of women with High-grade Squamous Intraepithelial Lesion (HSIL)   Immediate Loop Electrosurgical Excision or Colposcopic Examination  
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3 parts of Atypical Glandular Cell (AGC) work up   Colposcopy, endocervical brushing, endometrial biopsy  
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Preparing your patient for Colposcopy   refer to colposcopist, make sure she is not in her menses, premedicate with motrin 400-800mg to reduce cramps. Colposcopist will use vinegar and possibly Iodine (iodine stains only normal tissue): Lugols or Schiller test. Do a pregnancy test before.  
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Preparing your patient for what they can expect post-Colposcopy   expect mild cramping, discharge will be a mixture of blood and monsels (used to stop bleeding), will occasionally get an odor several days later due to a mild vaginal infection (10%)  
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CIN   Cervical Intraepithelial Neoplasia - used to describe abnormal tissue findings. Diagnostic term used from biopsy/colposcopy  
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Dysplasia   is a cytology dx, screening, from Pap smear  
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If you need to bx the anterior and posterior portion of the cervix, first bx   the posterior so that bleeding will not contaminate the anterior bx  
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Tx of cervical abnormalities   Cryotherapy of Cervix, LEEP (loop electrosurgical excision procedure), Laser, Cervical Conization  
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Risks of cervical tx   antibodies to sperm, cervical stenosis, incompetent cervix, missing a significant lesion  
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