Pharma antibiotics I facts from lecture
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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What is CCT? | Cancer chemotherapy. Therapy that distinguishes based on differences between normal and neoplastic. Treatment nonselective.
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What is ACT? | Exploit differences between pathogenic organism and host.
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What are the ways mechanisms of ACT? | 1)Inhibit cell wall synth 2)Alter cell wall perm 3)Inhibit protein synthesis 4)Inhibit nucleic acid synthesis 5)antimetabolite
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What is the log kill concept? | Each regin of CT kills constant %. ACT has much lower log kill than CCT.
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What is the bacteriostatic? What is MIC? | Inhibit growth of bacteria. MIC - Minimal inhibitory concentration.
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What is bacteriocidal? What is MBC? | Kill bacteria. MBC - Minimal bactericidal Conc. Usually MIC measured.
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What is the postantibiotic effect? (PAE) | PAE = T(time required for viable count to increase 10 times above count immediately before drug removed) - C (Time required for count in an untreated culture to increase 10 times above the count
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What are antibiograms? | The result of a lab testing for sensitivity of an isolated bacterial strain to antibiotics.
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What are the pharmacodynamic adverse effects of ABS?q | Ototoxicity, nephortoxicity
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What are the allergic SEs of penicillin? | Rash
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Can a superinfection result from antibiotics? | Yes, C. Diff
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