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Pharma antibiotics I facts from lecture

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Question
Answer
What is CCT?   Cancer chemotherapy. Therapy that distinguishes based on differences between normal and neoplastic. Treatment nonselective.  
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What is ACT?   Exploit differences between pathogenic organism and host.  
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What are the ways mechanisms of ACT?   1)Inhibit cell wall synth 2)Alter cell wall perm 3)Inhibit protein synthesis 4)Inhibit nucleic acid synthesis 5)antimetabolite  
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What is the log kill concept?   Each regin of CT kills constant %. ACT has much lower log kill than CCT.  
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What is the bacteriostatic? What is MIC?   Inhibit growth of bacteria. MIC - Minimal inhibitory concentration.  
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What is bacteriocidal? What is MBC?   Kill bacteria. MBC - Minimal bactericidal Conc. Usually MIC measured.  
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What is the postantibiotic effect? (PAE)   PAE = T(time required for viable count to increase 10 times above count immediately before drug removed) - C (Time required for count in an untreated culture to increase 10 times above the count  
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What are antibiograms?   The result of a lab testing for sensitivity of an isolated bacterial strain to antibiotics.  
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What are the pharmacodynamic adverse effects of ABS?q   Ototoxicity, nephortoxicity  
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What are the allergic SEs of penicillin?   Rash  
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Can a superinfection result from antibiotics?   Yes, C. Diff  
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