chapter 94 Dipiro's drugs
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| methotrexate (rheumatrex) | oral or IM: 7.5-15 mg q WEEK | CI in nursing preg liver or less than
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| leflunomide (arava) | oral 100 mg dialy for 3 days then 10-20 mg daily or 10-20 mg daily without loading dose | inhibit purine CI in liver disease contra nursing or pregers
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| hydroxychloroquine (plaquenil | oral 200-300 mg bid, after 1-2 months may decrease to 200 mg bid or daily | for pregers eye exam q 6 months
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| sulfasalazine (azulfadine) | 500 mg bid, then increase to 1 gram bid max | prodrug not for sulfa allergy, ADR limit use
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| etanercept (enbrel) | 50 mg SC wekkly | TNF inhibitors2 TNF receptors linked to an Fc fragment of human IgG1
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| inflixidmab (remicade) | 3 mg/kg IV at 0, 2, 6 weeks then q 8 weeks | TNF inhibitorchimeric anti-TNF antibody fused to a human constant region IgG1
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| adalimumab (Humira) | 40 mg SC q 2 weeks | TNF inhibitorHuman IgG1 antibody to TNF
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| anakinra (Kineret) | 100 mg SC daily | interleukin 1 inhibitor IL-1 receptor antagonist not to be used with TNF blocking agents
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| rituximab (Rituxan) | 1000 mg twice 2 weeks apart | depletes peripheral b cells
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| abatacept (Orencia | < 60 kg 500 mg60-100 kg 750 mg>100 kg 1000 mg | Prevent t-cell activationinhibits interaction between the anti presenting cells and T cells preventing T cells from activation to promote inflammatory process
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| cyclosporine | oral 2.5 mg/kg/day | reduces production of cytokines involved in T cell activation
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| azathioprine (imuran) | 50-100 mg daily | watch in renal dys fxn
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