Lipids and Dyslipoproteinemia
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Cholesterol travels in circulation in spherical particles containing both lipids and proteins. These particles are called? | lipoproteins
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what are the three main classes of lipoproteins measured in the serum | VLDL, LDL, HDL
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VLDL are composed mostly of? | triglycerides
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what is the main atherogenic class of lipoproteins | LDL
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How does HDL affect ones risk for development of atherosclerosis | inversely
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what is the optimal level for LDL | <100 (100-129 is near optimal/above optimal) and (130-159 is borderline high)
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what level of LDL is high | >160 ( > 190 is very high)
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what level of Total cholesterol is desirable | <200 (200-239 is borderline high)
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what level of total cholesterol is high | >240
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what level of HDL is desireable | >40 (<40 is low and >60 is high)
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what are the 5 modifiable CHD risk factors | 1) Smoking 2)Hypertension 3) Low HDL 4) Family Hx 5) Age
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oxidation of LDL has been shown to increase atherogenesis how can that be inhibited | anti-oxidants
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what is the only gentically determined component of lipoproteins | apolipoproteins
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what is the major protein component of HDL particles | Apolipoprotein A1
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what is the major protein component of LDl | Apolipoprotein B100
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how does Lp(a) affect thrombosis | Lp(a) can compete for the binding of plasminogen to its cell membrane receptor on the endothelial surface
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how does homocysteine enhance the atherosclerotic process | Generation of superoxide and hydrogen peroxide, enhanced coagulation, inhibiting dilation of small arteries, promoting smooth muscle proliferation
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what happens when Homocystein and LDL interact | they form LDL-homocysteine thiolactone aggregates which are taken up by macrophages and subsequently incorporated into foam cells in early atherosclerotic plaques
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how can you lower serum concentrations of homocysteine | treatment with daily supplements of folic acid, vitamins B6 and B12
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what is a better predictor of cardiovascular events fasting or non-fasting triglycerides | non-fasting triglycerides
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how are foam cells formed from LDL | Ox-LDL is taken up in macrophage scavenger receptors, promoting cholesterol ester accumulation and foam cell formation
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How is percentage error related to bias and CV as per NCEP guidelines | % total error = %bias + 1.96 * (%CV)
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What is the % total error acceptability limit for Total Cholesterol | <=9%
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What is the % total error acceptability limit for Triglycerides | <=15%
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What is the % total error acceptability limit for HDL Cholesterol | <=13%
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What is the % total error acceptability limit for LDL Cholesterol | <=12%
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What is the % total error for Cholesterol in a laboratory with a bias of 3.5% and a CV of 2% |
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For evaluation of elevated cholesterol levels, diabetic patients are treated like patients who already have CHD. Diabetes confers a high risk of new CHD within how many years? | 10 years
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ATP III (3rd report of NCEP 2002) , recognized for evaluation of elevated cholesterol levels which two conditions as candidates for intensive intervention and therapy | Metabolic Syndrome and patients with a high 10 year risk for CHD based on the Framingham risk projections
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Is the focus of NCSP guidelines on recognizing abnormal and normal cholesterol values | No, it is shifted to assessing overall cardiovascular risk based on cutoffs for cholesterol, triglycerides, HDL-C and LDL-C
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What are the tests recommended by ATP III as initial test for evaluating blood cholesterol | Complete lipoprotein profile - TC, LDL-C, HDL-C and Triglycerides
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how often should a fasting lipoprotein profile be obtained | in adults over 20 it should be obtained every 5 years
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In a patient that is non-fasting what parts of the fasting lipoprotein profile will be usable | the Total Cholesterol and HDL will be usable (get follow-up if TC is >200 or HDL is <40)
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What is the primary target for Cholesterol lowering therapy | LDL-C
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what is the LDL goal if you have CHD or CHD risk equivalents | <100
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what is the LDL goal if you have 2+ risk factors | <130
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what is the LDL goal if you have 0-1 risk factors | <160
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What are the two approaches used to reach LDL-C goal | Therapeutic lifestyle change (TLC) and drug therapy
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What are components of Therapeutic Lifestyle change | Dietary change and increased physical activity, combined with regular follow-up - this represents 1st line of therapy (may be combined initially with drug therapy in high risk patients)
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What are the drugs used for hyperlipidemia | Statins, fibric acid derivatives, bile acid resins, and nicotinic acid
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