Atropine Drug profile

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GENERIC NAME

None

BRAND NAME

Atropine

CLASS

Anticholinergic agent

MECHANISM OF ACTION

Parasympatholytic; Inhibits action of acetylcholine at postganglionic parasympathetic neuroeffector sites. Increases HR in life threatening bradyarrhythmias.

INDICATIONS

Hemodynamically unstable Bradycardia, Asystole, Bradycardic (<60 beats a minute) PEA, Organophosphate poisoning, bronchospastic pulmonary disorders.

CONTRAINDICATIONS

Tachycardia, Hypersensitivity, unstable cardiovascular status in acute hemorrhage and myocardial ischemia, narrow-angle glaucoma.

ADVERSE REACTIONS

Headache, dizziness, Palpitations, N/V, Tachycardia, arrhythmias, anticholinergic effects (blurred vision, dry mouth, urinary retention), paradoxical Bradycardia when pushed slowly or at low doses, flushed, hot, dry skin.

NOTES ON ADMINISTRATION

Pregnancy category C, Moderate doses may cause pupil dilation.

INCOMPATABILITIES/DRUG INTERACTIONS

Potential adverse effects when administered with digoxin, cholinergics, physostigmine. Effects enhanced by antihistamines, procainamide, quinidine, antipsychotics, benzodiazepines, and antidepressants.

DOSE/ROUTE; Adult,Asystole and Bradycardic PEA

1mg IV/IO push may repeat every 3-5 minutes up to 3 doses.

DOSE/ROUTE, ADULT, Unstable Bradycardia

0.5 mg IV/IO every 3-5 minutes not to exceed 3mg total.

DOSE/ROUTE, ADULT, Organophosphate Poisoning

Extremely large doses (2-4mg or higher)

DOSE/ROUTE,PEDEATRIC

0.02 mg/kg IV/IO push. May double for second dose. Minimum single dose is 0.1 mg.

DOSE/ROUTEChild

0.02 mg/kg IV/IO push. May double for second dose. Maximum single dose in child is 0.5mg. Max total dose is 1mg

DOSE, Adolescent single dose

1mg and total dose 2mg.