invasion bugs GI
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| infection: invasive pathogens to GI present with what? | Fecal leukocytes present, fever, blood in stoll
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| Salmonella characteristics | gram neg rod, non-lactose fermenter, produce H2S
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| Salmonella serotypes... (3) | O ag- somatic, H ag- flagella, Vi ag- capsular polysaccharide
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| Salmonella pathogenesis | sensitive to gastric acid (need large numbers for infection, Bacterial type III secretory system, survive intracellularly (in vacuoles then lyse)
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| S. enteritidis virulence | inflammatory diarrhea
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| Salmonella Typhi clinical characteristics | typhoid fever... fever, non-productive cough, skin develops rose spots
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| Salmonella typhi virulence | enters blood stream, little damage to intestine (little diarrhea), involvement with other organs
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| 3 salmonella manifestations | Enteritis, Septicemia, enteric fever
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| Salmonella Enteritis.... | most common form (6-48 hours after injection)
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| Salmonella Septicemia... | more prevalent in old young and immunocompromised
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| Salmonella Enteric Fever.... | Typhoid fever, bacteria pass through gastric cells and engulfed by macrophage, 10-14 days after ingestion, rose spots (skin lesions)
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| Salmonella on MacConkey | clear bc does NOT ferment lactose
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| Shigella characteristics... | non-motile gram neg, non-lactose fermenter, survive in CYTOPLASM, RESISTANT TO STOMACH ACIDS (few needed for infection)
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| Shigella Virulence... | type III secretion system, use host actin as rocket to propel to next cell
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| Shigella clinical features.... | dysentery, small volume stools, pain pooping, rarely enters bloodstream
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| Shigella treatment | fluids and electrolytes,, anti-diarrheal contraindicated
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| Campylobacter characteristics (leading cause of diarrheal illness in the US | gram neg curved rod, motile (flagella, can survive intracellularly in monocytes or intestinal ep. cells
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| Campylobacter Virulence | flagella, adhere, type III secretory system, inflammatory and bloody diarrhea
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| Campylobacter clinical presentation | watery stool, isolated on Campy BAP or Skirrow media, if symptoms longer then a week add antibiotics
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| Yersinia enterocolitica characterisitics | winter months, gram neg rod, invades mucous of terminal ilieum, often mistaken for appendicitis
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| Yersinia enterocolitica presentation | fever, 2-3 weeks with abdominal pain, not much diarrhea
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| Vibrio cholera characteristics... | curved gram neg rod w/ single FLAGELLA,
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| Vibrio cholera presentation,.... | voluminous watery diarrhea (rice-water), acute illness due to enterotoxin rapid loss of water (A-B toxin..A increases cAMP)
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| Vibrio cholera transmission.... | Contaminated water.... (seafood uncooked)
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| Vibrio cholera agar.... | TCBS agar
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| Vibrio parahaemolyticus characteristics | most virulent, salt loving, often found in undercooked shellfish, contaminated sushi, often seen in Japan
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Created by:
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