| Question |
 |
|
| Answer |
|
|
| Most grains are relatively poor sources of what 2 AAs? |
tryptophan and lysine |
| What 4 AAs are synthesized from the glycolytic pathway? |
Ser, Gly, Cys, Ala |
| What 4 AAs come from alpha-ketoglutarate? |
Arg, Glu, Gln, Pro |
| What 2 AAs come from Oxaloacetate? |
Asp, Asn |
| What two substrates are required to form serine? |
glucose and Glu |
| What is required for glycine to form serine or NH4? |
FH4 - tetrahydrofolate |
| What intermediate is necessary to form CO2 and H20 from glycine? |
glyoxalate |
| Cysteine is derived from what two AAs? |
Serine and Methionine |
| Cysteine is derived from what immediate intermediate? |
Cystathionine |
| What is cysteine broken down into? |
Sulfate - excreted in the urine |
| What is FH4? |
tetrahydrofolate |
| What 5 AAs have 5Cs, are interrelated metabolically, and are associated with alpha-ketoglutarate? |
Glu, Gln, Pro, Arg, His |
| What enzymes catalyzes the addition and removal of Amide N of Gln? |
glutamine synthase |
| Describe the histidine degradation pathway |
His, urocanate, FIGLU, glutamate |
| What are transamination reaction related to TCA cycle intermediates? |
OxAC to Asp, alpha-k-Glu to Glu, Pyr to Ala |
| What types of products do the degredation of glucogenic AAs produce? |
pyruvate |
| What types of products do the degredation of ketogenic AAs produce? |
acetyl CoA |
| What AAs are known to form fumarate during their catabolism? |
Phe, Tyr, Asp |
| What is PKU? |
phenylketonuria |
| What enzyme is defective in phenlyketonuria? |
phenylalanine hydroxylase |
| What are the 4 known defects in Tyr metabolism? |
tyrosinemia I and II, alcaptonuria, neotnatal tyrosinemia |
| What are the 4 AAs that form succinyl CoA? |
Met, Thr, Val, Ile |
| Conversion of propionyl CoA to Succinyl CoA require what cofactors? |
biotin and vitamin B12 |
| What is the intermediate between propionyl CoA to Succinyl CoA? |
methylmalonyl CoA |
| What is SAM? |
S-adenosyl Methionine |
| Describe the pathway from Met to Propionyl CoA. |
L-Met, SAM, SAH, L-Homocysteine, Cystathionine, alpha-ketobutyrate, Prop-CoA |
| What are the 2 fates of Thr catabolism |
Glycine and AcCoA |
| What is SAH? |
S-adenosyl Homocysteine |
| Elevated lvls of what AA intermediate are associated with heart disease? |
L-Homocysteine |
Buen Viaje lv.2 ch 8
