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| Answer |
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| STANDARD/TYPICAL/FIRST GENERATION ANTIPSYCHOTIC DRUGS |
THORAZINE, HALADOL***DOPAMINE ANTAGONIST |
| FUNCTIONS OF DOPAMINE |
CONTROLS MOVEMENT, PLEASURE, PROLACTIN RELEASE, POSITIVE AND NEGATIVE SYMPTOMS, AND TRIGGERS DELLUSIONS/HALLUCINATIONS |
| SIDE EFFECT OF FIRST GENERATION/TYPICAL/STANDARD ANTIPSYCHOTIC DRUGS |
BLOCKS TOO MUCH DOPAMINE AND CAUSES PARKINSONS SYMPTOMS |
| STANDARD/TYPICAL/FIRST GENERATION ANTIPSYCHOTIC DRUGS BLOCK WHAT NEUROTRANSMITTERS? |
ACETYLCHOLINE, NOREPINEPHERINE, HISTAMINE |
| ANTICHOLINERGIC SIDE EFFECTS |
DRY MOUTH BLURRED VISIO, URINARY RETENTION, CONSTIPATION, NAUSEA, GI UPSET, SKIN RASH, SEDATION, ORTHO HYPOTENSION, PHOTOSENSITIVITY (BLISTER FROM SUN), WGT GAIN, HORMONAL EFFECTS, EKG CHANGES |
| EXTRAPYRAMIDAL S/S..EPS |
PSEUDOPARKINSON-1-5 DAYS AFTR STRT, TREMORS, DROWLING,RIGIDITY..common in elder women w/dehyd,AKINESIS-MUSCLE WEAKNESS, AKATHESIS-RESTLESS, DYSTONIA-INVOL SPASM, OCULOGYRIC CRISIS-EYES ROLLING BACK..ER..COGENTIN, TARDIVE DYSKINESIA-BIZZARE FACIAL TICK |
| NEUROLEPTIC MALIGNAN SYNDROME |
BLOCKS TOO MUCH TO QUICK, S/S INC MUSCLE TONE, AUTONOMIC DYSFUNCTION..fever, labile hypertension, tachycardia, diaphoresis, drooling, myoglobinuria |
| HOW DO YOU TREAT NMS? |
D/C ANTIPSYCHOTIC, HYDRATE, ACETAMENOPHEN, HEPARIN, DANTOLENE(muscle relax)DOPAMINE..WAIT 1-2 WKS BEFORE RESTARTING ANTIPSYCHOTIC |
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