Comprehensive Pharm 10
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| MOA orlistat | inhibits pancreatic lipase
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| clinical use of orlistat | obesity management
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| toxcicity of orlistat | gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha
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| MOA sibutramine | sympathommimetic 5HT and NorE reuptake inhibitor
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| uses of sibutramine | short term and long term obesity management
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| toxicity of sibutramine | htn tachycardia
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| uses of GH | GH deficiency turner's syndrome
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| uses of somatostatin | acromegaly carcinoid gastrinoma glucagonoma
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| uses of octeroitide | (aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma
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| uses of adh | pituitary DI
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| MOA propylthiouracil | inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 --> T3
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| Which drugs block peptidoglycan cross-linking | Cephalosporin -cillins -nam/-nem
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| which drugs block peptidoglycan synthesis? | bacitracin vancomycin cycloserine
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| which drugs block bacterial/fungal cell wall synth | polymyxins
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| which drugs disrupt fungal cell membranes | amphotericin b nystatin -azoles
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| which drugs block NT synth | "Try my cell phone - I blocked the New Cleo" Sulfonamides trimethoprim
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| which drugs block DNA synth | "TOPless DANcing Queen" (insert abba song here... :) Topoisomerase Quinolones
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| which drugs block mRNA synth | rifampin
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| Which drugs block protein synth at the 50S subunit? | -mycins linezolid -gramins macrolides chloramphenicol
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| which drugs block protein synth at the 30S subunit | Aminoglycosides tetracyclines
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| MOA penicillin | it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes
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| uses for penicillin | gram + cocci and rods GNR spirochetes
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| which penicillins are the penicillinase resistant? | Nafcillin dicloxacillin methicillin
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| clinical uses for penicillinase resistant penicillins? | S. aureus (except for MRSA)
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| why are penicillinase resistant penicillins resistant to penicillinase | bulikier R group
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| how is MRSA resistant to methicillin | altered penicillin binding protein target site
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| adverse reaction to methicillin | interstitial nephritis
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| examples of aminopenicillins | ampicillin amoxicillin
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| what is clavulanic acid | penicillinase inhibitor
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| clinical uses for aminopenicillins | "ampicillin/amoxicillin HELPS kill enterococci" H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci
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| anti-pseudomonal drugs | "Take Piper in the Car, Sue" ticarcillin piperacillin carbenicillin
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| MOA cephalosporins | same as penicillins, less susceptible to penicillinases
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| uses for 1st generation cephalosporins | PEcK Proteus E coli Klebsiella
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| uses for 2nd generation cephalosporins | HEN PEcKS H. flu Enterobacter Neisseria Proteus E. coli Klebsiella Serratia
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| examples of 1st generation cephalosporins | "You FAILed the FIRST PHASE" cefazolin cephalexin
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| examples of 2nd generation cephalosporins | "Wait a SECOND! You SEE, FOX FUR is a FACt" cefoxitin cefuroxime cefaclor
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| 3rd generation cephalosporins | "If you are THIRsty, try a FOTO TAZER" Cefotaxime Ceftazidime ceftriaxone
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| clinical uses of aztreonam | klebsiella pseudomonas serratia (GNR only, nothing against gm + or anaerobes)
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| who is given aztreonam | penicillin allergic pts pts w renal insuff that can't tolerate aminoglycosides
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| what is cilastatin? | inhibits renal dihydropeptidase I always administered with imipenem
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| clinical uses for imipenem/meropenem? | gram + cocci GNR anaerobes
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| toxicity of imipenem, meropenem | gi distress rash seizures (all occcur at high plasma levels)
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| MOA aminoglycosides 'cidal/static? | inhibits formation of initiation complex --> misreads mRNA requires O2 for uptake, so won't work against anaerobes 'cidal
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| which drugs are aminoglycosides? | "Mean GNATS canNOT kill anaerobes" Gentamicin Neomycin Amikacin Tobramycin Streptomycin
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| toxicity of aminoglycosides | "Mean GNATS canNOT kill anaerobes" Nephrotoxicity (esp if used with cephalosporin) Ototoxicity (esp w/ loop diuretic) Teratogen
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| Uses for tetracyclines | VACUUM THe BedRoom Tunight V. cholera Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Burgodorferi Rickettsia
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| MOA tetracyclines 'cidal/static? | binds 30S and prevents attachment of aminoacyl RNA static
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| foods to avoid when takin tetracyclines | don't take with milk, iron, or antacids b/c it will inhibit absorption in gut
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| which tetracycline is fecally eliminated? | doxycycline (can be used in renal failure)
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| toxicity of tetracyclines | photosensitivity gi discomfort discoloration of teeth inhibits bone growth in kids
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| contraindications of tetracyclines | pregnancy
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| what drug can act as a diuretic in SIADH | demeclocycline (ADH antagonist)
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