Lymphatic system
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| Any substance that can induce a specific immune response is called a what? | Antigen
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| Nonspecific immune responses are called? | Innate
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| Specific immune responses are called? | Adaptive
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| Humoral response produces what? | Antibodies
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| The chief cellular constituents of the lymphatic system are the what? | Circulating lymphocytes
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| T-lymphocytes mature where? | Thymus
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| ________ T-lymphocytes interact with other cells to initiate immune responses. | Helper CD4+
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| ________ T-lymphocytes kill target cells. (ie virus infected cells, cancer cells, etc) | Cytotoxic CD8+
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| __________ differentiate in the bone marrow and participate in humoral immunity. | B-lymphocytes
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| What lymphocytes are specialized to kill transformed cells? | NK lymphocytes
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| Immunocompetent lymphocytes undergo __________ in secondary lymphoid tissues. | antigen dependent activation
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| Initial response to an antigen is what? | Inflammation
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| First encounter with an antigen uses what type of antibodies? | IgM
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| Secondary immune response uses what type of antibodies? | IgG
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| What are the 2 types of immune responses? | Humoral and cell mediated
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| Helper/cytotoxic T cells recognize and bind to antigens that are bound to what? | MHC molecules
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| What are the 2 classes of MHC molecules? | Class I and class II
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| What class of MHC molecules are present in all nucleated cells? | Class I
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| What class of MHC molecules are present on antigen presenting cells? | Class II
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| MHC I interact only with what? | CD8+ T cells
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| MHC II interact with only what? | CD4+ T cells
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| Lymphatic tissue that guards the alimentary tissue, respiratory passages and genitourinary tract is called what? | MALT (mucosa-associated lymphoid tissue)
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| Secondary nodules contain what that indicates an immune response is taking place? | Germinal center
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| Germinal centers are sites of what? | Proliferation and differentiation of lymphocytes, differentiation of plasma cells and production of antibodies.
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| Aggregations of nodules are usually seen in what 3 locations? | Tonsils, Peyer's patches,Vermiform appendix
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| Tonsils form a ring at the entrance of the what? | Oropharynx (Waldeyer's ring)
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| What are the 3 types of lymph node sinuses? | Subcapsular sinus, Trabecular sinus, Medullary sinus
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| Where to do lymphocytes enetr the node from the blood? | HEV (high endothelial venules)
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| Lymphocytes leave the node through what? | Efferent lymphatic vessels
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| Thymic medulla contains what unique feature? | Hassall's corpuscles
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| Hassall's corpuscles are what? | Concentrically arranged epithelioreticular cells
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| What prevents antigens from reaching the T cells? | Blood-thymus barrier
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| Components of the blood-thymus barrier are? | Endothelium, Basal lamina, Macrophages, Epithelioreticular cells
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| Thick accumulations of lymphocytes surrounding an artery is called what? | White pulp
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