Infections
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| Psuedomonas Aeruginosa | Gram Negative
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| Staphylococcus Aureus | Gram Positive
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| Inhibitors of 30S ribosomal subunit | Aminoglycocides
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| For P.aer, S. Aur | Aminoglycocides
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| 3 Major steps in Cell Wall Biosynthesis | Syn of murein monomers, Polymerization of murein Monomers, Cross linking of polymers
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| Streptococcus Pneumoniae | Gram Positive
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| Ampicillin | Hydrophilic
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| Amoxicillin | Hydrophilic
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| Pipercillin | Hydrophilic
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| Ticarcillin | Hydrophilic
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| Oxicillin | Hydrophobic
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| Cloxacillin | Hydrophobic
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| Methicillin | Hydrophobic
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| Penicillin G | Hydrophobic
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| Oxacillin | Hydrophobic - Semi-Synthetic Penicillin
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| Cloxacillin | Hydrophobic - Semi-Synthetic Penicillin
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| Dicloxacillin | Hydrophobic - Semi-Synthetic Penicillin
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| Nafcillin | Hydrophobic - Semi-Synthetic Penicillin
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| Mathicillin | Hydrophobic - Semi-Synthetic Penicillin
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| 1st Gen based on bacterial susceptibility | Cephazolin, Cefalexin, Cefradine (Cephalosporins)
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| 2nd Gen based on bacterial susceptibility | ?
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| 3rd Gen based on bacterial susceptibility | Ceftazidime, Cefizoxime, Cefoperazome
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| 4th Gen based on bacterial susceptibility | Cefeprime
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| Which Cephalosporins cause alcohol intolerance and increase clotting time | Cefotetan, Cefamandole, Cefoperazone
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| Vancomycin - MOA | Inhibit transglycosidation
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| Streptomycin | Obtained from streptomyces
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| Neomycin | Obtained from streptomyces
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| Kanamycin | Obtained from streptomyces
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| Tobramycin | Obtained from streptomyces
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| Amikacin | Obtained from micromonospora
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| Gentamicin | Obtained from micromonospora
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| which type of drugs are used for all three bacteria | penicillins and cephalosporins
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| what drug is used against methicillin resistant staphylococcus aureus | vancomycin
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| aminoglycosides are affective against | pseudomonas aeruginosa, staphylococcus aureus (NOT PNEUMONIAE)
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| three beta lactamase inhibitors | clavulanic acid, sulbactam tazobactam
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| what is the target of beta lactam antibiotics | transpeptidase
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| which type postive or neg have thick coat of murein | positive
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| which type of substances can easily pass through gram positive murine coat | hydrophilic
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| which + or - have a lipoteichoic acids for feeding, protection and adherence | gram +
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| Gram negative bacteria turn what color when stained with crystal violet | pink
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| which type - or + have thin coat of murein between two lipid bilayers | gram negative bacteria
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| which type + or - have lipoolysaccharides for protection adherence. (notice not say feeding) | gram negative bacteria
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| which type + or - can easily evade the host immune system do to pores and beta lactamases beging inside | gram negative
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| where does the synthesis of the murein monomer occur | intracellular in the cytoplasm
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| a murein is made of what | sugars and amino acids
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| where does the polymerization of murien monomers happen | cytoplasmic membrane because it is lipid mediated
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| where does cross linking of polymers in 2D lattices and 3D mats: | extracellular, in the periplasmic space between cytoplasmic membrane and murein layer
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| in which order are the sugar monomers formed | NAG then NAM
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| how does the rx of cell wall synthesis carried out | amidation,phosphorylation, acetylation,and addition rxn
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| what is the next step in cell wall biosynthesis after monomers are formed | the addition of peptide components alanine, glutamate, lysine (if neg DAP instead of lysine)
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| what is the last rxn before forming the park pepide | d-alanyl-D-alanine dipeptide added to UDP-NAM peptide to form park peptide by enzyme MurF
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