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Anemia

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Question
Answer
macrocytic anemia   folate, B12 deficiency, pernicious anemia , megaloblastic  
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pernicious anemia   lack of intrinsic factor  
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normocytic, normochromic   acute blood loss, aplastic anemia - marrow fails to make three types of blood cells - anemia, neutropenia (decrease WBCs), and thrombocytopenia (decrease platelets); drugs that cause this are felbamate, chloramphenicol, phenytoin  
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hypochromic, microcytic anemia   IDA, sickle cell, thalassemia  
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anemia of renal failure   lack of EPO  
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IDA labs lookl like...   decrease in ferritin, decrease in iron, decrease in Hgb, increase TIBC  
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IDA symptoms   koilonmychias, angular stomatitis, glossitis, pica  
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megaloblastic anemia looks like...   decrease in Hct, Hgb, decrease in RBC, increase in MCH  
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What has neuropsychiatric symptoms?   B12 deficiency, not folate  
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iron supplement PO per day   200 elemental per day  
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ferrous sulfate   65 mg; feosol, fer-in-sol  
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ferrous gluconate   35 mg; fergon  
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ferrous fumarate   99 mg; femiron, feostat  
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iron dextran   infed  
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iron sucrose   venofer  
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sodium ferric gluconate   ferlecitt  
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iron counseling points   take on empty stomach, can take with OJ, can use OTC docusate if have constipation  
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iron ADRs   dark colored stools, constipation, diarrhea, N/V  
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recommended daily intake of Vitamin B12   2 mcg/day  
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vegan should get this much B12 per day   1000 mcg/day  
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IM cyanocobalamine (B12)   1000 mcg IM QD x 1 week, then 100-1000 mcg QW x 4 weeks; then 100-1000 mcg QM  
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B12 ADRs   hyperuricemia, hypokalemia, sodium retention, cardiac problems, itching, diarrhea, anaphylaxis  
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EPO ADRs   immunogencity : pure red cell aplasia, increase in BP  
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Darbo ADRs   HTN, hypotension, edema, arrhythmia, N/V, diarrhea, constipation, fatigue, fever, HA, myalgia, arthralgia, limb pain, infection, dyspnea, cough  
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