drugs for class to know
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| zidovudine | AZT, ZDV | crosses blood brain barrier
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| didanosine | ddI | take with antacids
crosses BBB
use with caution in dementia cases
cause neuropathy
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| zalcitabine | ddC | use with caution in dementia cases
neuropathy
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| stavudine | d4T | crosses BBB
use with caution in dementia cases
causes neuropathy
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| lamivudine | 3TC | (blank)
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| abacavir | ABC | (blank)
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| tenofovir DF | TDF | eat with fatty meal
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| indinavir | IDV |
NO Antacids
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| ritonavir | RTV | Auto induction
inhibits 3A4
HIV-1 and HIV-2
increases cholesterol adn triglycerides
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| saquinavir | SQV |
take with fatty food
inhibits 3A4 the least of the PI's
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| nelfinavir | NFV | should eat with fatty meal
autoinduction
has active metabolite
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| lopinavir/ritonavir | LPV/r | eat with fatty meal
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| nevirapine | NVP | (blank)
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| delavirdine | DLV | (blank)
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| efavirenz | EFV | eat with fatty meal
use with caution in dementia cases
impaired concentration adn depersonalizaiton
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| atazanavir | ATV | fatty food increases bioavailability while increasing the pH redues bioavailability. so don't take with PPI, H2 antagonist or anacids
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| darunavir | (blank) | always used with ritonavir. food increase bioavailablity, may increase blood sugar, bleeding time, and change body fat distribution, AVOID if sulfa allergy, diabetic, hemophillia, liver problems
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| (abacavir + zidovudine + lamivudine), | (blank) | use with caution in dementia cases
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Popular Pharmacology sets