Stack #138507

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Answer

deltamethrin LD50 po

30-300mg/kg

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Deltamethrin dermal (insecticide chalk)

> 2000mg/kg

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DEET

N,N-diethyl-meta-toluamide

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picaridin (avon skin so soft, bug guard, cutter advanced 3-5 hours of effectiveness

2-(2-ydroxyethyl) piperidinecarboxylic 1-methylpropyl ESTER

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permethrin botanical insecticide ADI (pyrethrin 1, resmethrin, allethrin

0.05 mg/kg toxicity includes hyperexcitation, aggressiveness, startle response

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deltamethrin ADI (other type two include cypermethrin, fenvalerate

0.01mg/kg toxicity: clinic seizures, wrihing

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carbamate anticholinesterases

baygon, zectran, aldicarb temik, carbaryl(sevin)

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acetylcholine work by

acetylation

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organophates work by

phosphorylation

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carbamamates work by

arbamylation

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malathion (P-S bond) is inactivate by

hydrolysis

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malaoxon (P-O bond) is inactivated by

ACHE inhibition

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ANTIDOTAL treatment for anticholinesterase poisoning is

atropine (blocks ACHE receptors) OXIME (protopam/cholinesterase reactivator), diasepam, support respiration because this is primary cause of death

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organophosphates MOA with acetylcholine reactivation the K3 is

ultra rapid

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organophosphates MOA k3

very slow

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parathion with MFO in liver gives

paraoxon

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ACHE-paraoxan is

spontaneously reversible

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once paraoxon has be diethyl-phosphorlated ACHE it was become aged AGED-CHE and is not longer reversible there is no K$ with acethycholine

if put a flurin group there is no change to reverse

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the K3 of Paraoxon MOA may require what as an antidote

oxime antiodote

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tetraethyl pyrophosphate TEPP oral and dermal LD 50 is

1.1/2.4

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parathion LD 50 rat (oral / dermal

13/21

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malathion rat LD50 oral/dermal

1375/>4000

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DDVP dichiorvos LD50 (used in flea colars, past)

80/107

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tricholorofon LD50

630/2000

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methoxychlor requires P450 rxn its half life and LD50 are

2 week t1/2 and >6000mg/kg chance of resistance to those with p450 because this is the way it is rapidly cleared

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as you move up the ecosytem food chain you get bomagnnification and boactive body burdens can accumulated as much

345 times

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DDT has what kind of activity and is responsible for resproductive issues in animals and birds

estrogenic

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DDT and its metablolite is very lipid soluable and stay is the fat the metabolite are (DDE adn DDD) not DDA with is excreted in urine the half life of DDT is

1/2 to 1 year is the mammalin half life

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the oral LD 50 of DDT is

100-250 mg/kg

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the enzyme dehydrocholorinase will change DDT to lipid soluable form with a LD50 of

880mg/kg

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DDT will make metabolite that can be excreted in the urine with a LD 50 of

740 mg/kg

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oragnophosphates and carbamates MOA and target is

inhibition on ACHE

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phyrethroids (I and II), DDT MOA and targe

activation of sodium sodium channels

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dihyropyrazoles MOA and Target

inhibition and sodium channels

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rotenoids MOA and target

inhibition of mitochdrial comples I

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pyrethroids type II aslo MOA and targe

inhibition of GABA receptors-gated chloride channels

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a mechanistic attack that is used pyrethrioid resistance is MFO inhibitors and an examples is

piperonly butoxide that blocks the p450 detox

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Created by: lainylaina