| Flap 1 |
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| Flap 2 |
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| acetaminophen OD |
N-acetylcysteine (regenerates glutathione) |
| salicylate OD --> resp alk and metab acid |
NaHCO3 (alkanize urine), dialysis |
| amphetamine OD (basic) |
NH4Cl (acidify urine) |
| AChE inhibitor poisoning, organophosphates |
atropine (anti-muscarinic), pralidoxime (regenerates AChE) |
| antimuscarinic / anticholinergic poisoning |
physostigmine salicylate |
| atropine OD |
physostigmine salicylate |
| beta-blocker OD |
glucagon |
| verapamil OD |
glucagon |
| digitalis OD |
stop digitalis, normalize K+, lidocaine, anti-digitalis Fab fragments, Mg++ |
| iron poisoning |
deferoxamine |
| lead poisoning |
EDTA, dimercaprol, succimer, penicillamine |
| arsenic, MERcury, gold poisoning |
diMERcaprol, succimer |
| copper, aresenic, gold poisoning |
pencillamine ("copper pennies") |
| CN poisoning |
nitrite, hydroxocobalamin, thiosulfate |
| methemoglobin |
methylene blue |
| CO poisoning |
100% O2, hyperbaric O2 |
| methanol, ethylene glycol poisoning |
ethanol, dialysis, fomepizole (inhibits EtOH DH) |
| opioid OD |
naloxone/naltrexone |
| BZD OD |
flumazenil (competitive antag at GABA receptor) |
| TCA OD |
NaHCO3 (serum alkalinization) |
| heparin OD |
protamine |
| warfarin OD |
vit K, fresh frozen plasma (contains vit K factors) |
| tPA, streptokinase OD |
aminocaproic acid |
| encephalopathy, erythrocyte basophilic stippling |
lead poisoning; treat with EDTA |
| cell death due to peroxidation of membrane lipids, gastric bleeding, metab acid, scarring leading to GI obstruction |
iron poisoning; treat with deferoxamine |
| atropine-like SE |
TCA |
| coronary vasopasm |
cocaine, sumatriptan |
| cutaneous flushing |
niacine, Ca++ channel blockers, adenosine, vancomycin |
| DCM |
doxorubicin (Adriamycin), daunorubicin |
| torsades des pointes |
class IA (quinidine) and class III (sotalol) antiarrhythmics, cisapride (used in GI to increase ACh release --> improve transit time) |
| agranulocytosis |
clozapine, carbamazapine, colchicine, PTU, methimazole |
| aplastic anemia |
chloramphenicol, benzene, NSAIDs, PTU, methimazole |
| direct Coombs-positive hemolytic anemia |
methyldopa |
| gray baby syndrome |
chloramphenicol |
| hemolysis in G6PD deficient patients |
INH, sulfonamides, primaquine, high dose aspirin, ibuprofen, nitrofurantoin |
| thrombolytic complications |
OCPs |
| cough |
ACE inhibitors |
| pulmonary fibrosis |
bleomycin, busulfan, amiodarone |
| focal to massive hepatic necrosis |
halothane, valproic acid, acetaminophen, Amanita phalloides (mushroom) |
| hepatitis |
INH |
| pseudomembranous colitis |
clindamycin, ampicillin |
| adrenocoritcal insufficiency |
glucocorticoid withdrawl (HPA suppression) |
| gynecomastia |
spironolactone, digitalis, cimetidine, EtOH, ketoconazole (Some Drugs Cause Awesome Knockers), estrogen, marijuana |
| hot flahes |
tamoxifen, clomiphene |
| gingival hyperplasia |
phenytoin |
| gout |
furosemide, thiazides |
| osteoporosis |
corticosteroids, heparin |
| photosensitivity |
sulfonamides, amiodarone, tetracycline (SAT for a photo) |
| SLE-like syndromes |
hydralazine, phenytoin, INH, methyldopa, procainamide |
| tendonitis, tendon rupture, cartilage damage (in kids) |
fluoroquinolones |
| Fanconi's syndrome |
expired tetracycline, heavy metal exposure |
| interstitial nephritis |
methicillin, NSAIDs |
| hemorrhagic cystitis |
cyclophosphamide, ifosfamide; prevent by coadministering with mesna |
| disulfram-like reaction |
disulfram, metronidazole, 1st generation sulfonyurea, certain cephalopsporins, procarbazine, some HIV drugs |
| cinchonism (tinnitus, headache, nausea) |
quinidine, quinine |
| nephrogenic DI |
lithium, demeclocycline |
| seizures |
bupropion, imipenim/cilastatin, withdrawl from BZD/EtOH |
| tardive dyskinesia |
anti-psychotics |
| nephrotoxicity and neurotoxicity |
polymyxins |
| nephrotoxicity and ototoxicity |
aminoglycosides, loops, cisplatin, vancomycin |
| induce P450 |
BCG PQRS - barbituates, carbamazapine, griseofulvin, phenytoin, quinidine, rifampin, St. John's wort, EtOH |
| inhibit P450 |
PICK EGS - proteast inhibitor (HIV), INH, cimetidine, ketoconazole, erythromycin, grapefruit, sulfonamides |
| inhibits EtOH DH |
fomeprizole |
| inhibits acetylaldehyde DH |
disulfram |
| sulfa drugs |
TMP-SMX, sulfasalazine, sulfonyurea, celecoxib (COX-2 inhibitor), furosemide, thiazide |
