normal indicies and drug review
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| Q |  |
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| A | |
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| CO: | vol/min |
| CO= | 4-8 L/min |
| CI: | CO/BSA |
| CI= | 2.5-5.0 L/min/m2 |
| MAP: | [LVP + 2 (RAP)]/3 |
| MAP= | 80-100 mmHg |
| MPAP: | [RVP + 2 (LAP)]/3 |
| MPAP= | 10-20 mmHg |
| UO= | 60 mL/hr |
| CVP: | RAP, reflecting total vol. |
| CVP= | 2-6 mmHg |
| PCWP: | LAP=LVEDP |
| PCWP= | 4-12 mmHg |
| SVR: | [(MAP-CVP)*80]/CO |
| SVR= | 900-1400 dynes x s x cm5- |
| PVR: | { (PAP-CVP)* 80 } / (CO) |
| PVR= | 150-250 dynes x s x cm-5 |
| MC RMP= | -80 to -90 mV |
| affect of inhibiting Na+ influx into MC: | Phase 0 less steap/high, increased refractory time, decreased HR |
| Phase of MC AP involving Mg: | Phase 4 for function of NaK pump restoring ion balence |
| SA node rate= | 60-100 |
| AV junction rate= | 40-60 |
| Ventricle rate= | <40 |
| Absolute Refract: | P to mid T |
| Relative refract: | Mid to end T |
| Intropin 1-2 ug/kg/min: | promote renal, mesenteric blood flow? not |
| Intropin 2-10 ug/kg/min: | inotropic effects |
| Intropin >10 ug/kg/min: | vasopressor (constriction) |
| Dig FX | +contractility, -dromotropic |
| treat PACs: | verapamil, diltiazem |
| treat Afib/flut: | Ca++/B/Dig,Procainamide |
| treat SVT/PSVT: | adenosine, Ca/B/K block |
| treat Vtach/fib: | Epi/vasopressin, lidocaine, amiodorone, MgSO4, procain |
| I AA mechanism: | block influx of Na into both MC (phase 0) and PM cell (phase 4)... - conductivity and + refractory time; - automaticity (- HR) |
| II AA mechanism: | Block the B1 receptors |
| III AA mechanism: | slow efflux of K+ out MC, so repolarization +; +absolute refractory time; -conduction; -automaticity (- K out of cell, -phase 4 steepness |
| IV mechanism: | -Ca influx (-HR), prevents SM contraction, vascular relaxation |
| adenosine mechanism: | stimA1,-AV cond,-HR, +vasoD |
| MgSO4 mechanism: | return ion balence esp. during CPR |
| treat acute HT | Nipride |
| treat + precap arteriole R | Nipride, Adalat, Capoten, Vasotec |
| treat + precap venule R | Morphine |
| Persantine FX | (dypyrimidamole) inhibits platelet aggregation |
| Cardiazem FX | (diltiazem) -Mi02, -HR, vasoD |
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