Stack #120767
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| Neurodegenerative Diseases | Alzheimer's, ALS, Lou Gerhig's, Huntington's, Parkinson's
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| Causes of Deficits in Brain data processing | Injury, toxins, disinhibition
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| Most common from of dementia | Alz
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| Characteristic of Alz | Neurofibrillary Tangles and beta-amyloid Plaques
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| Theory of Alz | Inflammation response activated which kills all cells the area
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| Is it normal to have tangles? | Yes, they are part of the cytoskeleton
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| Is it normal to have plaques? | Yes, everyone has them
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| ______ is correlated to Alz. severity. | Tangles
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| Normal Tau protein uses | make microtubles, transport nutrients
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| The normal Tau protein is capped or uncapped. | capped to give it stability
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| bAAP | beta amyloid
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| bAAP gene is found on what chromosome | 21
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| bAAP leaves a fragment of what? | APP - protein amyloid precursor protein
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| Protein snipets are cleaned up in the Alz. brain? | no they clot and from amyloid plaques
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| Amyloid plaques gather where? | Between nerve cells
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| Amyloid plaque properites | insoluble, hard
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| Formation of B-amyloid plaques is a result from what? | missprocessing which lead to accumaltion of toxic levels of b-fragments
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| ____ and ____ possibly activate the inflammation response. | Free radicals and b-amyloid plaques
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| Cause of Alz | Genetic (apo E), Toxic exposure, Nutritional Disorders, Free Radicals
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| Apo E (Apoliprotein E) normally... | is a carrier of cholesterol in the blood
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| Mutated ApoE binds to.... | b-amyloid (makes it insolube) and Tau
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| The ventricals in an Alz brain are.. | Larger
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| Nutritional deficets that might lead to Alz. | Vit E, B12, Thiamin, Zinc, Acetyl 1-carnitine
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| Areas affected by Alz | Cereberal Cortex ( Frontal Lobe) and Hippocampus (brain stem) as well as cholingeric neurons
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| The Cerebral Cortex is where we find.. | reasoning, memory and learning
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| The temporal lobe is where we find... | memory formation
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| The Ventricles of an Alz brain are... | larger
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| Cholinergic neurons degenerated within... | 18 months
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| Gyri size in a Alz brain is.... | enlarged
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| The only Rx for Alz now | Aricept
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| Risk of Aricept | Brings ct back to place of awareness of actually having alz
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| Over time these skills/ areas are effected by Alz | language memory
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