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Most common congen anom of pancreas. failure of fusion of fetal duct systems of dorsal and ventral pancreatic primordia | Pancreas Divisum
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band like ring of panc tissue that completely encircles the 2nd part of duodenum. gastric distention and vomit | Annular Pancreas
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Reversible panc parenchymal injury associated w inflamm. Biliary tract disease and alcoholism account for most cases. foci of fat necrosis and red-black hemorrhage. Hereditary: inactivating mut in SPINK1 gene->active trypsin-> autodigestion. | Acute Pancreatitis
- High serum amylase, then high serum lipase
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inflamm of panc w irreversible destruction of endocrine parenchyma. Long Term Alcohol Abuse. PRSS1 and SPINK1 and CFTR gene muts associate. parenchymal fibrosis, reduced #/size of acini (spare islets of Langerhans), dilated panc ducts. ->DM | Chronic Pancreatitis
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benign cystic neoplasm of glycogen rich cuboid cells around small cyst of clear, thin, strawcolor fluid. Women >60. ab pain. Benign | Serous Cystadenomas
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painless, slow-growing mass, larger, filled w thick mucin, lined by columnar mucin-producing epithel w dense stroma. can be invasive. Women, body/tail of panc. | mucinous cystic neoplasm
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More common in Men, head of panc. lack dense "ovarian" stroma and involve large pancreatic ducts. can be malignant | Intraductal Papillary Mucinous Neoplasms (IPMNs)
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large, well-circumscribed mass, have solid and cystic components. activating Beta-catenin muts | Solid-pseudopapillary neoplasm
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Precursor lesions=panc intraepithel neoplasias (PanINs). KRAS most freq mut oncogene. p16/CDKN2A (w melanomas) most freq inactivated tumor suppressor gene, also SMAD4 and p53. Black Ashkenazi Jews b/w 60 and 80, and smoking. most in head of panc. | Pancreatic Carcinoma
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