Stack #108809
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| most resistant glass type for parenteral | type 1
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| three problems that could occur with plastics are ___-when the drug disolves the plastic and creates a hole,___-components of the container move into the contents, and ___-is where molecules bind to plastic | permeability, leaching, and sorption
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| of crystalline or amorphous with has a definite MP | cystalline
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| of crystalline or amorphous with is more soluble meaning less stable | amorphous
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| crystalline has ____arranged particles while amorphous has ____molecules | orderly, random
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| liquids cannot be formulated into solids with the exception of ____ and _____ | nitroglycerine and scopolamine (put it in its salt form
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| to increase the dissolution rate what do you need to do to particle size | decrease it
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| to increase bioavalibility what do you need to do to particle size | decrease it
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| if you decrease particle size all of the following will increase except dissolution rate, bioavailbility, or solubility | solubility is never associated with particle size
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| what it the biggest problem for drugs? bioavailibility or solubility | solubility
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| what is often the rate limiting step of drugs | dissolution rate
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| if a drug is insoluble what could you do to give it some aqueous solubility for therapeutic efficacy and enter systemic circulation | turn inot salt or ester form
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| which solubility class has high permeablity and high solubility | class one
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| the time it takes for a drug to dissolve in fluids at absorption site is referred to as | dissolution rate
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| what is a could estimate of membrance permeability | partition coefficient- measures how hydro-philic or phobic a drug is in octanol or water
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| if a drug has a high Partition coefficient is would preferentially distribute to hydro_____areas | hydrophobic areas the lipid bilayer
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| low partition coefficient with go to hydro___ areas | hydrophilic ares like blook serum
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| if a liquid drug is suseptable to hydrolysis you should | substitute with glycerin, propylene glycol, or alcohol
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| if an injectable drug is susceptible to hydrolysis you should use ___as solvent | anhydrous vegetable oils
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| if an antibiotic is susceptable to hydrolysis you should | not reconstitute until ready for use and refrig.
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| must drugs are stable at what pH? what could you use to increase stability | pH of 5-6 use a buffering agent to increase stability
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| all of the following are signs the drugs have been oxidize except: changed color, precipitation, producing an odor, or changed in molecular weight | the lose of electron won't change the MW.
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| an antioxidant use to prevent progression of chain reaction in aqueous solutions are the use of | sulfates such as sodium sulfate at high ph, sodium bisulfate(med), and sodium metabisulfate at low pH
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| examples of antioxidants that can be used to prevent oxidation in oleaginous preparations are | alphatocopherol and butyl hydroxyanisole
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Created by:
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