Control of Glomerular Filtration Rate
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| Question |
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| Answer |
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| What are 2 determinants of GFR? |
MAP, AFFERENT Arteriole diameter |
| How would increased Sympathetic activity affect GFR? |
Increase Sympathetic --> Vasoconstriction --> DECREASE GFR --> decrease Urine Output |
| How would decreased Symapathetic activity affect GFR? |
decrease Sympathetic --> Vasodilation --> INCREASE GFR --> increase Urine Output |
| What effect would Hemorage have on GFR and why? |
decrease Pressure --> decrease GFR --> conserve H2O and restore Blood volume |
| How do Epinephrine and Renin affect GFR? |
Vasoconstricting agents - constrict --> DECREASE GFR |
| Where does Epinephrine come from? |
Adrenal Medulla |
| Where does Renin come from? |
secreted by the cells of the Juxtaglomerular Complex |
| What effect do vasodilating agents have on GFR? give an example. |
dilate --> ^ GFR --> ^ UO |
| What 3 factors influence Afferent Arteriole diameter? |
relative Sympathetic activity, Vasoconstricting agents, Vasodilating agents |
| How does age affect GFR? |
DECREASE GFR - because of Atherosclerosis |
| How are BP and GFR correlated? |
^ BP --> ^ GFR and decrease BP --> decrease GFR |
| How is GFR measured? |
Liters filtered per day - average 93 mm Hg |
| Where does MAP affect GFR? |
Global - from the whole body |
| Where doe Afferent Arteriole diameter affect GFR? |
Local = best - affect GFR moment to moment |
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