| Question |
Answer |
| What are the aerosolized antiinfectives we have learned about? |
Pentamidine-Nebupent, Ribavirin-Virazole, Tobramycin-TOBI, Zanamivir-Relenza |
| What is the recommended dosage for Pentamidine/NebuPent? |
300mg/6ml sterile water; once/4wks |
| What is the recommended dosage for Ribavirin/Virazole? |
20mg/ml; 12-18hrs/day for 3-7days by SPAG |
| What is the recommended dosage for Tobramycin?TOBI? |
300mg bid; 28 days on/28 days off; >6yrs |
| What is the recommended dosage for Zanamivir/Relenza? |
10mg bid with DPI diskhaler; bid 5 days |
| What are the indications for Pentamidine/NebuPent? |
PCP prophylaxis in HIV pt |
| What are the indications for Ribavirin/Virazole? |
RSV |
| What are the indications for Tobramycin/TOBI? |
P. aeruginosa in CF |
| What are the indications for Zanamivir/Relenza? |
Influenza |
| What is the mode of action for Ribavirin/Virazole? |
Inhibits DNA replication/reproduction |
| What special precautions should be taken when delivering Ribavirin/Virazole? |
PPE's should always be worn; Women who are pregnant or planning pregnancy should not administer |
| What special precautions should be taken when administering Pentamidine/NebuPent? |
Use Respigard II neb system, administer in negative pressure room or under exhaust, always wear PPEs |
| What is the mode of action for Pentamidine/Virazole? |
Inhibits DNA, RNA, phospholipids and protein synthesis |
| What is the mode of action for Ribavirin/Virazole? |
Stops viral DNA replication |
| What is the mode of action for Tobramycin/TOBI? |
Bacterialcidal - blocks protein synthesis |
| What is the mode of action for Zanamivir/Relenza? |
Binds to viral enzyme and block action |
| What are the side effects of Tobramycin/TOBI and Gentamicin? |
Dizziness, nausea, neuromuscular blockade; |
| What can worsen the side effects of TOBI and Gentamicin? |
Myasthenia and use of neuromuscular blockades |
Cardio Block2anatomy
